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Craniofacial Fibrous Dysplasia: Retrospective Study on the Relationship Between the Tumor Volume Changes and the Circulating Serum Calcitonin and Serum Alkaline Phosphatase

 Hussein, Mohammed Ahmed  ;  Yun, In Sik  ;  Kim, Bo Ok  ;  Kim, Yong Oock 
 Annals of Plastic Surgery, Vol.78(3) : 289-293, 2017 
Journal Title
 Annals of Plastic Surgery 
Issue Date
Adolescent ; Adult ; Alkaline Phosphatase/blood* ; Biomarkers/blood ; Calcitonin/blood* ; Child ; Facial Bones/diagnostic imaging ; Facial Bones/pathology* ; Facial Bones/surgery ; Female ; Fibrous Dysplasia, Polyostotic/blood ; Fibrous Dysplasia, Polyostotic/diagnostic imaging ; Fibrous Dysplasia, Polyostotic/pathology* ; Fibrous Dysplasia, Polyostotic/surgery ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Postoperative Period ; Preoperative Period ; Retrospective Studies ; Skull/diagnostic imaging ; Skull/pathology* ; Skull/surgery ; Tomography, X-Ray Computed ; Tumor Burden* ; Young Adult
craniofacial fibrous dysplasia ; alkaline phosphatase ; calcitonin ; tumor volume ; bone segmentation
BACKGROUND: The purpose of this study was to determine the usefulness of serum alkaline phosphatase (ALP) and calcitonin in the follow-up of tumor volume changes in patients with craniofacial fibrous dysplasia. METHODS: Twenty patients with isolated craniofacial fibrous dysplasia were included, who met our criteria for long-term follow-up. Three-dimensional computed tomography scans were obtained, and tumor segmentation was performed. The tumor volume was measured preoperatively, immediate postoperative and during long-term follow-up. Serum ALP and calcitonin levels were obtained at the same times to assess their correlation with tumor volumes. RESULTS: Preoperative calcitonin levels were correlated with the presence of tumor (P = 0.0442), whereas ALP levels were not (P = 0.1125). There were no significant associations between tumor volume and ALP or calcitonin levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP was significantly associated with tumor recurrence (P = 0.0096), but serum calcitonin was not (P = 0.4760). However, serum levels of ALP did not reflect the tumor volume changes. CONCLUSIONS: Serum ALP may be useful as a laboratory test for follow-up of patients with isolated craniofacial fibrous dysplasia. However, it cannot represent the tumor's volume changes and 3-dimensional computed tomography scans with tumor volume measurement are mandatory for detecting significant volume changes during follow-up. Investigation of the serum calcitonin in the preoperative period is also recommended on a large scale because it was related to the presence of the tumor.
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1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
김용욱(Kim, Yong Oock) ORCID logo https://orcid.org/0000-0002-3756-4809
윤인식(Yun, In Sik) ORCID logo https://orcid.org/0000-0003-1103-7047
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