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Craniofacial Fibrous Dysplasia: Retrospective Study on the Relationship Between the Tumor Volume Changes and the Circulating Serum Calcitonin and Serum Alkaline Phosphatase
DC Field | Value | Language |
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dc.contributor.author | 김용욱 | - |
dc.contributor.author | 윤인식 | - |
dc.date.accessioned | 2017-11-02T08:28:59Z | - |
dc.date.available | 2017-11-02T08:28:59Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0148-7043 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154515 | - |
dc.description.abstract | BACKGROUND: The purpose of this study was to determine the usefulness of serum alkaline phosphatase (ALP) and calcitonin in the follow-up of tumor volume changes in patients with craniofacial fibrous dysplasia. METHODS: Twenty patients with isolated craniofacial fibrous dysplasia were included, who met our criteria for long-term follow-up. Three-dimensional computed tomography scans were obtained, and tumor segmentation was performed. The tumor volume was measured preoperatively, immediate postoperative and during long-term follow-up. Serum ALP and calcitonin levels were obtained at the same times to assess their correlation with tumor volumes. RESULTS: Preoperative calcitonin levels were correlated with the presence of tumor (P = 0.0442), whereas ALP levels were not (P = 0.1125). There were no significant associations between tumor volume and ALP or calcitonin levels in the preoperative or postoperative periods. During long-term follow-up, serum ALP was significantly associated with tumor recurrence (P = 0.0096), but serum calcitonin was not (P = 0.4760). However, serum levels of ALP did not reflect the tumor volume changes. CONCLUSIONS: Serum ALP may be useful as a laboratory test for follow-up of patients with isolated craniofacial fibrous dysplasia. However, it cannot represent the tumor's volume changes and 3-dimensional computed tomography scans with tumor volume measurement are mandatory for detecting significant volume changes during follow-up. Investigation of the serum calcitonin in the preoperative period is also recommended on a large scale because it was related to the presence of the tumor. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Little, Brown And Company | - |
dc.relation.isPartOf | ANNALS OF PLASTIC SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Alkaline Phosphatase/blood* | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Calcitonin/blood* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Facial Bones/diagnostic imaging | - |
dc.subject.MESH | Facial Bones/pathology* | - |
dc.subject.MESH | Facial Bones/surgery | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibrous Dysplasia, Polyostotic/blood | - |
dc.subject.MESH | Fibrous Dysplasia, Polyostotic/diagnostic imaging | - |
dc.subject.MESH | Fibrous Dysplasia, Polyostotic/pathology* | - |
dc.subject.MESH | Fibrous Dysplasia, Polyostotic/surgery | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postoperative Period | - |
dc.subject.MESH | Preoperative Period | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Skull/diagnostic imaging | - |
dc.subject.MESH | Skull/pathology* | - |
dc.subject.MESH | Skull/surgery | - |
dc.subject.MESH | Tomography, X-Ray Computed | - |
dc.subject.MESH | Tumor Burden* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Craniofacial Fibrous Dysplasia: Retrospective Study on the Relationship Between the Tumor Volume Changes and the Circulating Serum Calcitonin and Serum Alkaline Phosphatase | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Plastic Surgery & Reconstructive Surgery | - |
dc.contributor.googleauthor | Hussein, Mohammed Ahmed | - |
dc.contributor.googleauthor | Yun, In Sik | - |
dc.contributor.googleauthor | Kim, Bo Ok | - |
dc.contributor.googleauthor | Kim, Yong Oock | - |
dc.identifier.doi | 10.1097/SAP.0000000000000917 | - |
dc.contributor.localId | A02588 | - |
dc.contributor.localId | A00749 | - |
dc.relation.journalcode | J00176 | - |
dc.identifier.eissn | 1536-3708 | - |
dc.identifier.pmid | 27922893 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000637-201703000-00012&LSLINK=80&D=ovft | - |
dc.subject.keyword | craniofacial fibrous dysplasia | - |
dc.subject.keyword | alkaline phosphatase | - |
dc.subject.keyword | calcitonin | - |
dc.subject.keyword | tumor volume | - |
dc.subject.keyword | bone segmentation | - |
dc.contributor.alternativeName | Kim, Yong Oock | - |
dc.contributor.alternativeName | Yun, In Sik | - |
dc.contributor.affiliatedAuthor | Yun, In Sik | - |
dc.contributor.affiliatedAuthor | Kim, Yong Oock | - |
dc.citation.title | Annals of Plastic Surgery | - |
dc.citation.volume | 78 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 289 | - |
dc.citation.endPage | 293 | - |
dc.identifier.bibliographicCitation | ANNALS OF PLASTIC SURGERY, Vol.78(3) : 289-293, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43563 | - |
dc.type.rims | ART | - |
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