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Prognostic Significance of Vas Deferens Invasion After Radical Prostatectomy in Patients with Pathological Stage T3b Prostate Cancer

Authors
 Won Sik Jang  ;  Cheol Yong Yoon  ;  Ki Hong Kim  ;  Yong Jin Kang  ;  Su-Jin Shin  ;  Nam Hoon Cho  ;  Joo Yong Lee  ;  Kang Su Cho  ;  Won Sik Ham  ;  Koon Ho Rha  ;  Sung Joon Hong  ;  Young Deuk Choi 
Citation
 Annals of Surgical Oncology, Vol.24(4) : 1143-1149, 2017 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2017
MeSH
Aged ; Disease-Free Survival ; Humans ; Kaplan-Meier Estimate ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Staging ; Neoplasm, Residual ; Proportional Hazards Models ; Prostate-Specific Antigen/blood ; Prostatectomy ; Prostatic Neoplasms/blood ; Prostatic Neoplasms/pathology* ; Prostatic Neoplasms/surgery* ; Retrospective Studies ; Seminal Vesicles/pathology ; Vas Deferens/pathology*
Keywords
Radical Prostatectomy ; Seminal Vesicle ; National Comprehensive Cancer Network ; Androgen Deprivation Therapy ; National Comprehensive Cancer Network
Abstract
BACKGROUND: Seminal vesicle invasion (SVI) is associated with adverse clinical outcomes in prostate cancer (PCa) patients. Despite its anatomical similarity and close proximity to the seminal vesicle, the prognostic significance of vas deferens invasion (VDI) by PCa has not been elucidated. For these reasons, we investigated the impact of VDI on the oncological outcome of pT3b PCa in association with SVI. METHODS: We retrospectively reviewed the medical records of 3359 patients who had undergone a radical prostatectomy at our institution between January 2000 and December 2014 for PCa. Patients who received neoadjuvant or adjuvant treatment (radiation, androgen deprivation therapy, or both) and those without adequate medical records were excluded. A Kaplan-Meier analysis was performed to analyze biochemical recurrence-free survival (BCRFS), and a Cox regression model was used to test the influence of VDI on biochemical recurrence (BCR). RESULTS: Of 350 patients with pathologically confirmed SVI (pT3b), 87 (24.9%) had VDI, while the remaining 263 patients (75.1%) had isolated SVI. Compared with SVI patients without VDI, SVI patients with VDI were noted to have a significantly worse 5-year BCRFS (25.1 vs. 17.1%, respectively). VDI was a significant predictor of BCR in multivariate Cox regression analysis (hazard ratio 1.39, 95% confidence interval 1.02-1.90; p = 0.039). CONCLUSIONS: Our results shows that the prognosis of PCa with SVI might be further stratified by VDI status, thus suggesting the role of VDI either as a surrogate for poor prognosis or as a determinant for adjuvant therapy.
Full Text
https://link.springer.com/article/10.1245%2Fs10434-016-5653-x
DOI
10.1245/s10434-016-5653-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강용진(Kang, Yong Jin)
나군호(Rha, Koon Ho) ORCID logo https://orcid.org/0000-0001-8588-7584
신수진(Shin, Su Jin)
윤철용(Yoon, Cheol Yong)
이주용(Lee, Joo Yong) ORCID logo https://orcid.org/0000-0002-3470-1767
장원식(Jang, Won Sik) ORCID logo https://orcid.org/0000-0002-9082-0381
조강수(Cho, Kang Su) ORCID logo https://orcid.org/0000-0002-3500-8833
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
최영득(Choi, Young Deuk) ORCID logo https://orcid.org/0000-0002-8545-5797
함원식(Ham, Won Sik) ORCID logo https://orcid.org/0000-0003-2246-8838
홍성준(Hong, Sung Joon) ORCID logo https://orcid.org/0000-0001-9869-065X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154494
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