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Characterizing amide proton transfer imaging in haemorrhage brain lesions using 3T MRI

Authors
 Ha-Kyu Jeong  ;  Kyunghwa Han  ;  Jinyuan Zhou  ;  Yansong Zhao  ;  Yoon Seong Choi  ;  Seung-Koo Lee  ;  Sung Soo Ahn 
Citation
 European Radiology, Vol.27(4) : 1344-1351, 2017 
Journal Title
 European Radiology 
ISSN
 0938-7994 
Issue Date
2017
MeSH
Acute Disease ; Amides ; Brain/diagnostic imaging ; Brain/pathology ; Brain Mapping/methods* ; Brain Neoplasms/diagnostic imaging* ; Brain Neoplasms/pathology ; Cerebral Hemorrhage/diagnostic imaging* ; Cerebral Hemorrhage/pathology ; Female ; Humans ; Magnetic Resonance Imaging/methods* ; Male ; Middle Aged ; Protons ; White Matter/diagnostic imaging ; White Matter/pathology
Keywords
Amide proton transfer imaging ; Brain neoplasms ; Cerebral haemorrhage ; Magnetic resonance imaging ; Magnetization transfer
Abstract
OBJECTIVES: The aim of this study was to characterize amide proton transfer (APT)-weighted signals in acute and subacute haemorrhage brain lesions of various underlying aetiologies. METHODS: Twenty-three patients with symptomatic haemorrhage brain lesions including tumorous (n = 16) and non-tumorous lesions (n = 7) were evaluated. APT imaging was performed and analyzed with magnetization transfer ratio asymmetry (MTR asym ). Regions of interest were defined as the enhancing portion (when present), acute or subacute haemorrhage, and normal-appearing white matter based on anatomical MRI. MTR asym values were compared among groups and components using a linear mixed model. RESULTS: MTR asym values were 3.68 % in acute haemorrhage, 1.6 % in subacute haemorrhage, 2.65 % in the enhancing portion, and 0.38 % in normal white matter. According to the linear mixed model, the distribution of MTR asym values among components was not significantly different between tumour and non-tumour groups. MTR asym in acute haemorrhage was significantly higher than those in the other regions regardless of underlying pathology. CONCLUSIONS: Acute haemorrhages showed high MTR asym regardless of the underlying pathology, whereas subacute haemorrhages showed lower MTR asym than acute haemorrhages. These results can aid in the interpretation of APT imaging in haemorrhage brain lesions. KEY POINTS: Acute haemorrhages show significantly higher MTR asym values than subacute haemorrhages. • MTR asym is higher in acute haemorrhage than in enhancing tumour tissue. • MTR asym in haemorrhage does not differ between tumorous and non-tumorous lesions.
Full Text
https://link.springer.com/article/10.1007%2Fs00330-016-4477-1
DOI
10.1007/s00330-016-4477-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Choi, Yoon Seong(최윤성)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154483
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