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The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

Authors
 Won Sik Jang  ;  Kang Su Cho  ;  Myung Soo Kim  ;  Cheol Yong Yoon  ;  Dong Hyuk Kang  ;  Yong Jin Kang  ;  Won Sik Jeong  ;  Won Sik Ham  ;  Young Deuk Choi 
Citation
 Oncotarget, Vol.8(7) : 11778-11787, 2017 
Journal Title
 Oncotarget 
Issue Date
2017
MeSH
Aged ; Humans ; Lymphocytes/pathology* ; Male ; Middle Aged ; Neutrophils/pathology* ; Prognosis ; Prostatectomy/methods* ; Prostatic Neoplasms/blood* ; Prostatic Neoplasms/surgery* ; Retrospective Studies
Keywords
biochemical recurrence ; neutrophil-to-lymphocyte ratio ; prostate cancer ; radical prostatectomy ; survival
Abstract
BACKGROUND: The pretreatment neutrophil-to-lymphocyte ratio has prognostic value after radical prostatectomy for treating localized prostate cancer. However, the use of postoperative neutrophil-to-lymphocyte ratio has not been evaluated in this population. We investigated the prognostic significance of early postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for prostate cancer. METHODS: We retrospectively reviewed clinical data from 2,302 patients with localized prostate cancer who underwent radical prostatectomy at our institution between years 2000 and 2010. Only patients with pre- and postoperative complete blood counts with differential results were included. Patients who received neoadjuvant or postoperative adjuvant treatment and those without adequate medical records were excluded. Kaplan-Meier analyses were performed to analyze biochemical recurrence-free survival and overall survival rates. Univariate and multivariate Cox regression models were used for each endpoint. RESULTS: Kaplan-Meier curves showed that high postoperative neutrophil-to-lymphocyte ratio (>3.5) was significantly associated with decreased biochemical recurrence-free survival (p = 0.009) and overall survival (p = 0.010). In the univariate and multivariate Cox regression analyses, high postoperative neutrophil-to-lymphocyte ratio was a significant predictor of biochemical recurrence (hazard ratio 1.270, p = 0.008) and overall survival (hazard ratio 1.437, p = 0.033). CONCLUSIONS: Our results demonstrate that postoperative neutrophil-to-lymphocyte ratio is an independent factor for biochemical recurrence and overall survival in patients who underwent radical prostatectomy for prostate cancer. These findings suggest that neutrophil-to-lymphocyte ratio can be a potentially valuable tool for stratifying high-risk patients and facilitating choices of postoperative therapy in patients with prostate cancer.
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DOI
10.18632/oncotarget.14349
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Dong Hyuk(강동혁)
Kang, Yong Jin(강용진)
Kim, Myung Soo(김명수)
Yoon, Cheol Yong(윤철용)
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
Jeong, Won Sik(정원식)
Cho, Kang Su(조강수) ORCID logo https://orcid.org/0000-0002-3500-8833
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154479
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