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The prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer

DC FieldValueLanguage
dc.contributor.author강동혁-
dc.contributor.author강용진-
dc.contributor.author김명수-
dc.contributor.author윤철용-
dc.contributor.author정원식-
dc.contributor.author조강수-
dc.contributor.author최영득-
dc.contributor.author함원식-
dc.date.accessioned2017-11-02T08:26:52Z-
dc.date.available2017-11-02T08:26:52Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154479-
dc.description.abstractBACKGROUND: The pretreatment neutrophil-to-lymphocyte ratio has prognostic value after radical prostatectomy for treating localized prostate cancer. However, the use of postoperative neutrophil-to-lymphocyte ratio has not been evaluated in this population. We investigated the prognostic significance of early postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for prostate cancer. METHODS: We retrospectively reviewed clinical data from 2,302 patients with localized prostate cancer who underwent radical prostatectomy at our institution between years 2000 and 2010. Only patients with pre- and postoperative complete blood counts with differential results were included. Patients who received neoadjuvant or postoperative adjuvant treatment and those without adequate medical records were excluded. Kaplan-Meier analyses were performed to analyze biochemical recurrence-free survival and overall survival rates. Univariate and multivariate Cox regression models were used for each endpoint. RESULTS: Kaplan-Meier curves showed that high postoperative neutrophil-to-lymphocyte ratio (>3.5) was significantly associated with decreased biochemical recurrence-free survival (p = 0.009) and overall survival (p = 0.010). In the univariate and multivariate Cox regression analyses, high postoperative neutrophil-to-lymphocyte ratio was a significant predictor of biochemical recurrence (hazard ratio 1.270, p = 0.008) and overall survival (hazard ratio 1.437, p = 0.033). CONCLUSIONS: Our results demonstrate that postoperative neutrophil-to-lymphocyte ratio is an independent factor for biochemical recurrence and overall survival in patients who underwent radical prostatectomy for prostate cancer. These findings suggest that neutrophil-to-lymphocyte ratio can be a potentially valuable tool for stratifying high-risk patients and facilitating choices of postoperative therapy in patients with prostate cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfOncotarget-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHHumans-
dc.subject.MESHLymphocytes/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeutrophils/pathology*-
dc.subject.MESHPrognosis-
dc.subject.MESHProstatectomy/methods*-
dc.subject.MESHProstatic Neoplasms/blood*-
dc.subject.MESHProstatic Neoplasms/surgery*-
dc.subject.MESHRetrospective Studies-
dc.titleThe prognostic significance of postoperative neutrophil-to-lymphocyte ratio after radical prostatectomy for localized prostate cancer-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorWon Sik Jang-
dc.contributor.googleauthorKang Su Cho-
dc.contributor.googleauthorMyung Soo Kim-
dc.contributor.googleauthorCheol Yong Yoon-
dc.contributor.googleauthorDong Hyuk Kang-
dc.contributor.googleauthorYong Jin Kang-
dc.contributor.googleauthorWon Sik Jeong-
dc.contributor.googleauthorWon Sik Ham-
dc.contributor.googleauthorYoung Deuk Choi-
dc.identifier.doi10.18632/oncotarget.14349-
dc.contributor.localIdA04711-
dc.contributor.localIdA05091-
dc.contributor.localIdA04988-
dc.contributor.localIdA05180-
dc.contributor.localIdA03801-
dc.contributor.localIdA04111-
dc.contributor.localIdA04337-
dc.contributor.localIdA04870-
dc.contributor.localIdA05268-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid28052031-
dc.subject.keywordbiochemical recurrence-
dc.subject.keywordneutrophil-to-lymphocyte ratio-
dc.subject.keywordprostate cancer-
dc.subject.keywordradical prostatectomy-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKang, Dong Hyuk-
dc.contributor.alternativeNameKang, Yong Jin-
dc.contributor.alternativeNameKim, Myung Soo-
dc.contributor.alternativeNameYoon, Cheol Yong-
dc.contributor.alternativeNameJeong, Won Sik-
dc.contributor.alternativeNameCho, Kang Su-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.alternativeNameHam, Won Sik-
dc.contributor.affiliatedAuthorKang, Yong Jin-
dc.contributor.affiliatedAuthorKim, Myung Soo-
dc.contributor.affiliatedAuthorYoon, Cheol Yong-
dc.contributor.affiliatedAuthorJeong, Won Sik-
dc.contributor.affiliatedAuthorCho, Kang Su-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.contributor.affiliatedAuthorHam, Won Sik-
dc.contributor.affiliatedAuthorKang, Dong Hyuk-
dc.citation.titleOncotarget-
dc.citation.volume8-
dc.citation.number7-
dc.citation.startPage11778-
dc.citation.endPage11787-
dc.identifier.bibliographicCitationOncotarget, Vol.8(7) : 11778-11787, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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