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N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection

Authors
 Sungil Jang  ;  Eun-Jung Bak  ;  Jeong-Heon Cha 
Citation
 JOURNAL OF MICROBIOLOGY, Vol.55(5) : 396-402, 2017 
Journal Title
 JOURNAL OF MICROBIOLOGY 
ISSN
 1225-8873 
Issue Date
2017
MeSH
Blotting, Western ; Cell Line ; Enzyme-Linked Immunosorbent Assay ; Epithelial Cells/microbiology* ; Epithelial Cells/physiology* ; Extracellular Signal-Regulated MAP Kinases/analysis ; Helicobacter pylori/immunology* ; Humans ; Interleukin-8/metabolism* ; MAP Kinase Kinase Kinases/metabolism* ; MAP Kinase Signaling System ; Proto-Oncogene Proteins/metabolism*
Keywords
Helicobacter pylori ; IL-8 ; cot ; erk activation ; mapk pathway
Abstract
Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC. The H. pylori load and histopathological scores of stomachs were measured in Mongolian gerbils infected with H. pylori strain 7.13, and fed with NAC-containing diet. In liquid culture, NAC inhibited H. pylori growth in a concentration-dependent manner. In the animal model, 3-day administration of NAC after 1 week from infection reduced the H. pylori load; 6-week administration of NAC after 1 week from infection prevented the development of gastritis and reduced H. pylori colonization. However, no reduction in the bacterial load or degree of gastritis was observed with a 6-week administration of NAC following 6-week infection period. Our results indicate that NAC may exert a beneficial effect on reduction of bacterial colonization, and prevents the development of severe inflammation, in people with initial asymptomatic or mild H. pylori infection.
Full Text
https://link.springer.com/article/10.1007%2Fs12275-017-7089-9
DOI
10.1007/s12275-017-7089-9
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154423
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