Cited 13 times in
N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection
DC Field | Value | Language |
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dc.contributor.author | 차정헌 | - |
dc.date.accessioned | 2017-11-02T08:24:03Z | - |
dc.date.available | 2017-11-02T08:24:03Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1225-8873 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154423 | - |
dc.description.abstract | Helicobacter pylori (H. pylori) is a human gastric pathogen, causing various gastric diseases ranging from gastritis to gastric adenocarcinoma. It has been reported that combining N-acetylcysteine (NAC) with conventional antibiotic therapy increases the success rate of H. pylori eradication. We evaluated the effect of NAC itself on the growth and colonization of H. pylori, and development of gastritis, using in vitro liquid culture system and in vivo animal models. H. pylori growth was evaluated in broth culture containing NAC. The H. pylori load and histopathological scores of stomachs were measured in Mongolian gerbils infected with H. pylori strain 7.13, and fed with NAC-containing diet. In liquid culture, NAC inhibited H. pylori growth in a concentration-dependent manner. In the animal model, 3-day administration of NAC after 1 week from infection reduced the H. pylori load; 6-week administration of NAC after 1 week from infection prevented the development of gastritis and reduced H. pylori colonization. However, no reduction in the bacterial load or degree of gastritis was observed with a 6-week administration of NAC following 6-week infection period. Our results indicate that NAC may exert a beneficial effect on reduction of bacterial colonization, and prevents the development of severe inflammation, in people with initial asymptomatic or mild H. pylori infection. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Microbiological Society of Korea | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Epithelial Cells/microbiology* | - |
dc.subject.MESH | Epithelial Cells/physiology* | - |
dc.subject.MESH | Extracellular Signal-Regulated MAP Kinases/analysis | - |
dc.subject.MESH | Helicobacter pylori/immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Interleukin-8/metabolism* | - |
dc.subject.MESH | MAP Kinase Kinase Kinases/metabolism* | - |
dc.subject.MESH | MAP Kinase Signaling System | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism* | - |
dc.title | N-acetylcysteine prevents the development of gastritis induced by Helicobacter pylori infection | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Biology | - |
dc.contributor.googleauthor | Sungil Jang | - |
dc.contributor.googleauthor | Eun-Jung Bak | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.identifier.doi | 10.1007/s12275-017-7089-9 | - |
dc.contributor.localId | A03440 | - |
dc.contributor.localId | A04007 | - |
dc.relation.journalcode | J01593 | - |
dc.identifier.eissn | 1976-3794 | - |
dc.identifier.pmid | 28455589 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12275-017-7089-9 | - |
dc.subject.keyword | Helicobacter pylori | - |
dc.subject.keyword | IL-8 | - |
dc.subject.keyword | cot | - |
dc.subject.keyword | erk activation | - |
dc.subject.keyword | mapk pathway | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Jang, Sungil | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.citation.title | Journal of Microbiology | - |
dc.citation.volume | 55 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 396 | - |
dc.citation.endPage | 402 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY, Vol.55(5) : 396-402, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42998 | - |
dc.type.rims | ART | - |
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