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Correlation of Serum Creatine Kinase Level With Pulmonary Function in Duchenne Muscular Dystrophy

Other Titles
 뒤시엔느 근디스트로피 환자에서 혈청 크레아틴 키나아제 수준과 호흡 기능과의 연관성 
 Eun Young Kim  ;  Jang Woo Lee  ;  Mi Ri Suh  ;  Won Ah Choi  ;  Seong Woong Kang  ;  Hyeon Jun Oh 
 Annals of Rehabilitation Medicine, Vol.41(2) : 306-312, 2017 
Journal Title
Annals of Rehabilitation Medicine
Issue Date
Creatine kinase ; Duchenne muscular dystrophy ; Respiratory function tests
OBJECTIVE: To investigate the relationship between serum creatine kinase (CK) level and pulmonary function in Duchenne muscular dystrophy (DMD).

METHODS: A total of 202 patients with DMD admitted to the Department of Rehabilitation Medicine, Gangnam Severance Hospital were enrolled from January 1, 1999 to March 31, 2015. Seventeen patients were excluded. Data collected from the 185 patients included age, height, weight, body mass index, pulmonary function tests including forced vital capacity (FVC), peak cough flow, maximal expiratory pressure (MEP), and maximal inspiratory pressure (MIP), and laboratory measurements (serum level of CK, CK-MB, troponin-T, and B-type natriuretic peptide). FVC, MEP, and MIP were expressed as percentages of predicted normal values.

RESULTS: Serum CK activities were elevated above normal levels, even in the oldest DMD group. Serum CK level was strongly correlated with pulmonary functions of sitting FVC (p<0.001), supine FVC (p<0.001), MIP (p=0.004), and MEP (p<0.001).

CONCLUSION: Serum CK level is a reliable screening test even in patients with advanced DMD, and is a strong predictor of pulmonary functions.
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1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Kim, Eun Young(김은영)
Suh, Mi Ri(서미리)
Oh, Hyeon Jun(오현준)
Choi, Won Ah(최원아) ORCID logo https://orcid.org/0000-0003-0403-8869
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