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White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

Authors
 Youn Wook Chung  ;  Faiyaz Ahmad  ;  Yan Tang  ;  Steven C. Hockman  ;  Hyun Jung Kee  ;  Karin Berger  ;  Emilia Guirguis  ;  Young Hun Choi  ;  Dan M. Schimel  ;  Angel M. Aponte  ;  Sunhee Park  ;  Eva Degerman  ;  Vincent C. Manganiello 
Citation
 Scientific Reports, Vol.7 : 40445-40445, 2017 
Journal Title
 Scientific Reports 
ISSN
 2045-2322 
Issue Date
2017
Abstract
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, which encodes PDE3B, an enzyme that catalyzes hydrolysis of cAMP and cGMP and is highly expressed in tissues that regulate energy homeostasis, including adipose tissue, liver, and pancreas. In epididymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated, resulting in "browning" phenotype, with a smaller increases in body weight under high-fat diet, smaller fat deposits, increased β-oxidation of fatty acids (FAO) and oxygen consumption. Results reported here suggest that PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue, and potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders.
Files in This Item:
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DOI
10.1038/srep40445
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소)
Yonsei Authors
기현정(Kee, Hyun Jung) ORCID logo https://orcid.org/0000-0003-4350-1852
정연욱(Chung, Youn Wook) ORCID logo https://orcid.org/0000-0002-4382-1410
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154309
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