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Prevalence of Metabolic Syndrome in Patients with Schizophrenia in Korea: A Multicenter Nationwide Cross-Sectional Study

 Jung Sun Lee  ;  Jun Soo Kwon  ;  Daeho Kim  ;  Sung-Wan Kim  ;  Jae-Jin Kim  ;  Jong-Hoon Kim  ;  Hee Jung Nam  ;  Seunghyong Ryu  ;  Il Ho Park  ;  Suk Kyoon An  ;  Hong-Seok Oh  ;  Seunghee Won  ;  Kanguk Lee  ;  Kyu Young Lee  ;  Seung-Hwan Lee  ;  Yu Sang Lee  ;  Jung-Seo Yi  ;  Kyung Sue Hong  ;  Yeon Ho Joo 
 PSYCHIATRY INVESTIGATION, Vol.14(1) : 44-50, 2017 
Journal Title
Issue Date
Antipsychotics ; Korean population ; Metabolic syndrome ; Schizoaffective disorder ; Schizophrenia
OBJECTIVE: We designed a nationwide study with limited exclusion criteria to investigate the prevalence of metabolic syndrome (MetS) in Korea and its relationship with antipsychotic medications. METHODS: This multicenter, cross-sectional, and observational study included patients diagnosed with schizophrenia or schizoaffective disorder. Sixteen hospitals enrolled 845 patients aged 18 to 65 years prescribed any antipsychotic medication between August 2011 and August 2013. MetS was diagnosed using the criteria of the modified Adult Treatment Panel III of the National Cholesterol Education Program with the Korean abdominal obesity definition (waist circumference ≥85 cm in women, ≥90 cm in men). RESULTS: The prevalence of MetS in all patients was 36.5% and was significantly higher in men than women (men, 40.8%; women, 32.2%) and was significantly correlated with age [odds ratio (OR) 1.02] and duration of illness (OR 1.03). The prevalence of MetS across antipsychotic drugs in the major monotherapy group was as follows: 18.8% for quetiapine, 22.0% for aripiprazole, 33.3% for both amisulpride and paliperidone, 34.0% for olanzapine, 35% for risperidone, 39.4% for haloperidol, and 44.7% for clozapine. CONCLUSION: The prevalence of MetS is very high in patients with schizophrenia or schizoaffective disorder. Screening and monitoring of MetS is also strongly recommended.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
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