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Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods

Authors
 Haein Kim  ;  Yong Taek Jeong  ;  Min Sung Choi  ;  Jaekyun Choi  ;  Seok Jun Moon  ;  Jae Young Kwon 
Citation
 MOLECULES AND CELLS, Vol.40(5) : 331-338, 2017 
Journal Title
 MOLECULES AND CELLS 
ISSN
 1016-8478 
Issue Date
2017
MeSH
Animals ; Animals, Genetically Modified ; Drosophila Proteins/genetics* ; Drosophila Proteins/metabolism ; Drosophila melanogaster/physiology* ; Feeding Behavior/drug effects ; Gene Expression Regulation ; Pharynx/cytology ; RNA Interference ; Receptors, Cell Surface/genetics* ; Receptors, Cell Surface/metabolism ; Sensory Receptor Cells/cytology* ; Sensory Receptor Cells/drug effects ; Sensory Receptor Cells/physiology ; Sodium Chloride/pharmacology* ; Taste Buds/drug effects
Keywords
Drosophila melanogaster ; feeding ; gustatory receptor ; pharyngeal sense organ
Abstract
Regulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.
Files in This Item:
T201701903.pdf Download
DOI
10.14348/molcells.2017.0028
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Jeong, Yong Taek(정용택) ORCID logo https://orcid.org/0000-0003-0067-6396
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154257
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