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Involvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods

DC FieldValueLanguage
dc.contributor.author문석준-
dc.contributor.author정용택-
dc.date.accessioned2017-11-02T08:15:20Z-
dc.date.available2017-11-02T08:15:20Z-
dc.date.issued2017-
dc.identifier.issn1016-8478-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154257-
dc.description.abstractRegulation of feeding is essential for animal survival. The pharyngeal sense organs can act as a second checkpoint of food quality, due to their position between external taste organs such as the labellum which initially assess food quality, and the digestive tract. Growing evidence provides support that the pharyngeal sensory neurons regulate feeding, but much is still unknown. We found that a pair of gustatory receptor neurons in the LSO, a Drosophila adult pharyngeal organ which expresses four gustatory receptors, is involved in feeding inhibition in response to high concentrations of sodium ions. RNAi experiments and mutant analysis showed that the gustatory receptor Gr2a is necessary for this process. This feeding preference determined by whether a food source is perceived as appetizing or not is influenced by nutritional conditions, such that when the animal is hungry, the need for energy dominates over how appealing the food source is. Our results provide experimental evidence that factors involved in feeding function in a context-dependent manner.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Molecular and Cellular Biology-
dc.relation.isPartOfMolecules and Cells-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAnimals, Genetically Modified-
dc.subject.MESHDrosophila Proteins/genetics*-
dc.subject.MESHDrosophila Proteins/metabolism-
dc.subject.MESHDrosophila melanogaster/physiology*-
dc.subject.MESHFeeding Behavior/drug effects-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHPharynx/cytology-
dc.subject.MESHRNA Interference-
dc.subject.MESHReceptors, Cell Surface/genetics*-
dc.subject.MESHReceptors, Cell Surface/metabolism-
dc.subject.MESHSensory Receptor Cells/cytology*-
dc.subject.MESHSensory Receptor Cells/drug effects-
dc.subject.MESHSensory Receptor Cells/physiology-
dc.subject.MESHSodium Chloride/pharmacology*-
dc.subject.MESHTaste Buds/drug effects-
dc.titleInvolvement of a Gr2a-Expressing Drosophila Pharyngeal Gustatory Receptor Neuron in Regulation of Aversion to High-Salt Foods-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Biology-
dc.contributor.googleauthorHaein Kim-
dc.contributor.googleauthorYong Taek Jeong-
dc.contributor.googleauthorMin Sung Choi-
dc.contributor.googleauthorJaekyun Choi-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorJae Young Kwon-
dc.identifier.doi10.14348/molcells.2017.0028-
dc.contributor.localIdA03663-
dc.contributor.localIdA01358-
dc.relation.journalcodeJ02273-
dc.identifier.pmid28535667-
dc.subject.keywordDrosophila melanogaster-
dc.subject.keywordfeeding-
dc.subject.keywordgustatory receptor-
dc.subject.keywordpharyngeal sense organ-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNameJeong, Yong Taek-
dc.contributor.affiliatedAuthorJeong, Yong Taek-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.citation.titleMolecules and Cells-
dc.citation.volume40-
dc.citation.number5-
dc.citation.startPage331-
dc.citation.endPage338-
dc.identifier.bibliographicCitationMolecules and Cells, Vol.40(5) : 331-338, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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