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Premorbid exercise engagement and motor reserve in Parkinson's disease

Authors
 Mun K. Sunwoo  ;  Ji E. Lee  ;  Jin Y. Hong  ;  Byung S. Ye  ;  Hye S. Lee  ;  Jungsu S. Oh  ;  Jae S. Kim  ;  Phil H. Lee  ;  Young H. Sohn 
Citation
 Parkinsonism & Related Disorders, Vol.34 : 49-53, 2017 
Journal Title
 Parkinsonism & Related Disorders 
ISSN
 1353-8020 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Corpus Striatum/diagnostic imaging ; Dopamine Plasma Membrane Transport Proteins/metabolism* ; Exercise/physiology* ; Female ; Humans ; Male ; Mental Status Schedule ; Middle Aged ; Motor Activity/physiology* ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/physiopathology* ; Parkinson Disease/rehabilitation* ; Positron-Emission Tomography ; Prospective Studies ; Retrospective Studies ; Severity of Illness Index ; Tropanes/pharmacokinetics
Keywords
Cognitive reserve ; Motor cortex ; Parkinson' disease: imaging ; Parkinson's disease ; Parkinson's disease : neurophysiology ; Plasticity
Abstract
BACKGROUND: Life-long experiences of cognitive activity could enhance cognitive reserve, which may lead individuals to show less cognitive deficits in Alzheimer's disease, despite similar pathological changes. We performed this study to test whether premorbid physical activity may enhance motor reserve in Parkinson's disease (PD) (i.e., less motor deficits despite similar degrees of dopamine depletion). METHODS: We assessed engagement in premorbid leisure-time exercise among 102 drug naive PD patients who had been initially diagnosed at our hospital by dopamine transporter scanning. Patients were classified into tertile groups based on the frequency, duration, and intensity of the exercises in which they participated. RESULTS: Among patients with mild to moderate reductions in striatal dopaminergic activity (above the median dopaminergic activity), the exercise group of the highest tertile showed significantly lower motor scores (i.e., fewer motor deficits, 15.53 ± 6.25), despite similar degrees of dopamine reduction, compared to the combined group of the middle and the lowest tertiles (21.57 ± 8.34, p = 0.01). Nonetheless, the highest tertile group showed a more rapid decline in motor function related to reductions in striatal dopaminergic activity than the other two groups (p = 0.002 with the middle tertile group and p = 0.001 with the lowest tertile group). CONCLUSIONS: These results suggest that engagement in premorbid exercise acts as a proxy for an active reserve in the motor domain (i.e., motor reserve) in patients with PD.
Full Text
http://www.sciencedirect.com/science/article/pii/S135380201630428X
DOI
10.1016/j.parkreldis.2016.10.023
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
선우문경(Sunwoo, Mun Kyung)
손영호(Sohn, Young Ho) ORCID logo https://orcid.org/0000-0001-6533-2610
예병석(Ye, Byoung Seok) ORCID logo https://orcid.org/0000-0003-0187-8440
이지은(Lee, Ji Eun)
이필휴(Lee, Phil Hyu)
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154154
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