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Sequential healing of onlay bone grafts using combining biomaterials with cross-linked collagen in dogs

Authors
 Jae Kook Cha  ;  Myung-Jae Joo  ;  Sora Yoon  ;  Jung-Seok Lee  ;  Seong-Ho Choi  ;  Ui-Won Jung 
Citation
 CLINICAL ORAL IMPLANTS RESEARCH, Vol.28(1) : 76-85, 2017 
Journal Title
CLINICAL ORAL IMPLANTS RESEARCH
ISSN
 0905-7161 
Issue Date
2017
MeSH
Animals ; Biocompatible Materials* ; Bone Transplantation/methods* ; Collagen/administration & dosage* ; Cross-Linking Reagents ; Dogs ; Inlays/methods* ; Maxilla/anatomy & histology ; Maxilla/diagnostic imaging ; Maxilla/surgery ; Wound Healing/physiology* ; X-Ray Microtomography
Keywords
animal experiments ; bone substitutes ; guided bone regeneration ; material science ; wound healing
Abstract
OBJECTIVES: The aim of this study was to observe the sequential healing of onlay grafts in terms of the volumetric and histologic changes using different bone substances and absorbable membranes according to the presence of collagen cross-linking.

MATERIAL AND METHODS: Four groups involving onlay grafting with different materials were randomly assigned to both sides of the maxillae of 15 beagle dogs: (i) control group without any treatment; (ii) group NN, bovine hydroxyapatite incorporated into a non-cross-linked collagen matrix (BHC) + non-cross-linked collagen membrane (NCCM); (iii) group NC, BHC + cross-linked collagen membrane (CCM); and (iv) group CC, porcine hydroxyapatite incorporated into a cross-linked collagen matrix + CCM. Radiographic and histological analyses were performed after three different healing periods: 4, 8 and 12 weeks.

RESULTS: At week 4, the bone substances were well localized under the barrier membrane in groups NC and CC, while the bone substances became spread out and flattened in group NN. Similarly, the augmented height was significantly greater in groups NC and CC (2.55 and 2.51 mm, respectively; median) than in group NN (1.96 mm, P < 0.001, both). The percentages of newly formed bone were significantly higher at week 12 than at weeks 4 and 8 in all of the groups. The NCCM showed an earlier angiogenesis pattern than the CCM; however, earlier degradation was observed at week 12.

CONCLUSION: Combining biomaterials with cross-linked collagen might contribute to maintaining its initial morphology with excellent biocompatibility in early healing period of lateral onlay grafts.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/clr.12763/abstract
DOI
10.1111/clr.12763
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Joo, Myung Jae(주명재)
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154142
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