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Root coverage using porcine collagen matrix with fibroblast growth factor-2: a pilot study in dogs

Authors
 Jae Kook Cha  ;  Yoo-Kyung Sun  ;  Jung-Seok Lee  ;  Seong-Ho Choi  ;  Ui-Won Jung 
Citation
 JOURNAL OF CLINICAL PERIODONTOLOGY, Vol.44(1) : 96-103, 2017 
Journal Title
JOURNAL OF CLINICAL PERIODONTOLOGY
ISSN
 0303-6979 
Issue Date
2017
Keywords
collagen matrix ; fibroblast growth factor ; periodontal regeneration ; root coverage
Abstract
AIM: The aim of this study was to evaluate the effect of fibroblast growth factor-2 (FGF-2) in combination with porcine collagen matrix (CM) for coverage of gingival recession defects in dogs.

MATERIALS AND METHODS: In five male mongrel dogs, labial gingival recession defects were surgically created in the lower-third incisors bilaterally. The defects were randomly assigned to the CM/FGF-2 group (experimental) or the CM-only group (control). Standardized clinical photographs and silicone impressions were taken at 4 and 16 weeks of healing to calculate the remaining recession area. The dogs were euthanized after 16 weeks for histometric analysis.

RESULTS: At 4 weeks, the recession area of the CM/FGF-2 group was significantly smaller than that of the CM-only group (2.55 ± 0.66 and 4.92 ± 1.05 mm2 , respectively, p = 0.023), However, no significant difference was observed at 16 weeks. Histometrically, the amount of newly formed cementum was larger in the CM/FGF-2 group than in the CM-only group at 16 weeks (1.55 ± 0.44 and 0.88 ± 0.51 mm, respectively, p = 0.024).

CONCLUSIONS: The combination of CM/FGF-2 may enhance the early wound healing and may promote cementum formation to a higher extent compared to the use of CM alone.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/jcpe.12644/abstract
DOI
10.1111/jcpe.12644
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Sun, Yoo Kyung(선유경)
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Cha, Jae Kook(차재국) ORCID logo https://orcid.org/0000-0001-6817-9834
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154118
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