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Practical Performance of the 2015 American Thyroid Association Guidelines for Predicting Tumor Recurrence in Patients with Papillary Thyroid Cancer in South Korea

Authors
 Lee Seul Gi  ;  Lee Woo Kyung  ;  Lee Hye Sun  ;  Moon Jieun  ;  Lee Cho Rok  ;  Kang Sang Wook  ;  Jeong Jong Ju  ;  Nam Kee-Hyun  ;  Chung Woong Youn  ;  Jo Young Suk  ;  Lee Jandee 
Citation
 Thyroid, Vol.27(2) : 174-181, 2017 
Journal Title
 Thyroid 
ISSN
 1050-7256 
Issue Date
2017
MeSH
Adult ; Carcinoma, Papillary/epidemiology* ; Disease-Free Survival ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neck Dissection* ; Neoplasm Recurrence, Local/pathology ; Neoplasm Recurrence, Local/surgery* ; Neoplasm Staging ; Practice Guidelines as Topic ; Prognosis ; Republic of Korea/epidemiology ; Retrospective Studies ; Risk Assessment ; Thyroid Neoplasms/epidemiology* ; Thyroidectomy*
Keywords
papillary thyroid cancer ; practice guidelines ; predictive accuracy ; recurrence ; risk stratification
Abstract
BACKGROUND: The 2015 American Thyroid Association (ATA) management guidelines for adult patients with differentiated thyroid cancer propose the use of the modified initial risk stratification and response to therapy re-stratification systems. This study was conducted to validate the practicality of the revised guidelines for predicting tumor recurrence in patients with differentiated thyroid cancer. METHODS: Patients with papillary thyroid cancer (n = 2425) who underwent total thyroidectomy with central neck node dissection with or without modified radical neck node dissection at a single institution between October 1985 and July 2009 were retrospectively enrolled. The accuracy of three different risk-stratification strategies for predicting disease-free survival, set out in the 2009 and 2015 ATA management guidelines, was assessed: the initial risk stratification (ATA 2009-RSS), the modified initial risk stratification (ATA 2015-RSS), and the response to therapy re-stratification (ATA 2015-RTR). RESULTS: After applying the ATA 2015-RSS, 258/1913 (13.5%) of patients originally designated as intermediate risk by the ATA 2009-RSS were designated as low risk. This was mainly due to the small number of metastatic lymph nodes. Recurrence was detected in 136 (5.6%) patients during follow-up. Of the 2425 cases examined, 375 were designated as low risk by the ATA 2009-RSS, with a recurrence rate of 1.1%. However, the ATA 2015-RSS designated 633 (26.1%) cases as low risk, with a recurrence rate of 0.9%. Implementing the ATA 2015-RTR predicted an excellent response in 1597 (65.9%) cases, with a recurrence rate of 1.1%. According to the proportion of variance explained (PVE), the Akaike information criterion, Harrell's c index, and integrated area under the curve, comparing the predictive accuracy of the ATA 2009-RSS, ATA 2015-RSS, and ATA 2015-RTR revealed that the ATA 2015-RTR was a superior predictor of recurrence. CONCLUSIONS: A proportion of patients designated as intermediate risk by the ATA 2009-RSS were designated as low risk by the ATA 2015-RSS. The ATA 2015-RTR may be the most accurate predictor of risk of recurrence.
Full Text
http://online.liebertpub.com/doi/10.1089/thy.2016.0252
DOI
10.1089/thy.2016.0252
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
강상욱(Kang, Sang Wook) ORCID logo https://orcid.org/0000-0001-5355-833X
남기현(Nam, Kee Hyun) ORCID logo https://orcid.org/0000-0002-6852-1190
이슬기(Lee, Seul Gi) ORCID logo https://orcid.org/0000-0003-3233-7823
이우경(Lee, Woo Kyung) ORCID logo https://orcid.org/0000-0002-6737-3173
이잔디(Lee, Jan Dee) ORCID logo https://orcid.org/0000-0003-4090-0049
이초록(Lee, Cho Rok) ORCID logo https://orcid.org/0000-0001-7848-3709
이혜선(Lee, Hye Sun) ORCID logo https://orcid.org/0000-0001-6328-6948
정웅윤(Chung, Woung Youn)
정종주(Jeong, Jong Ju) ORCID logo https://orcid.org/0000-0002-4155-6035
조영석(Jo, Young Suk) ORCID logo https://orcid.org/0000-0001-9926-8389
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153454
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