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Neutrophil Extravasation Cascade: What Can We Learn from Two-photon Intravital Imaging?

Authors
 Sang A Park  ;  Young-Min Hyun 
Citation
 IMMUNE NETWORK, Vol.16(6) : 317-321, 2016 
Journal Title
IMMUNE NETWORK
ISSN
 1598-2629 
Issue Date
2016
Keywords
Intravital imaging ; Microparticle formation ; Neutrophil extravasation ; Two-photon microscopy
Abstract
Immune cells (leukocytes or white blood cells) move actively and sensitively based on body conditions. Despite their important role as protectors inside the body, it is difficult to directly observe the spatiotemporal momentum of leukocytes. With advances in imaging technology, the introduction of two-photon microscopy has enabled researchers to look deeper inside tissues in a three-dimensional manner. In observations of immune cell movement along the blood vessel, vascular permeability and innate immune cell movements remain unclear. Here, we describe the neutrophil extravasation cascade, which were observed using a two-photon intravital imaging technique. We also provide evidence for novel mechanisms such as neutrophil body extension and microparticle formation as well as their biological roles during migration.
Files in This Item:
T201606180.pdf Download
DOI
10.4110/in.2016.16.6.317
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153159
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