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Reactive Oxygen Species are Involved in Y-27632-induced Neurite Outgrowth in PC12 Cells

Authors
 So Yeong Park  ;  Seong Ah Moon  ;  Jeong Mi An  ;  Du sik Kim  ;  Jeong Taeg Seo 
Citation
 International Journal of Oral Biology, Vol.41(4) : 231-236, 2016 
Journal Title
International Journal of Oral Biology
ISSN
 1226-7155 
Issue Date
2016
Abstract
Inhibition of Rho-associated coiled coil-containing kinase (ROCK) has been reported to promote differentiation of neuronal cells. Here, we examined the effect of Y-27632, a ROCK inhibitor, on the outgrowth of neurites in PC12 cells. Y-27632 caused a rapid induction of neurite outgrowth in PC12 cells in a time-dependent manner. The neurite outgrowth, triggered by Y-27632, was accompanied by Rac1 activation, and was attenuated by Rac1 inhibitor NSC23766, in a concentration-dependent manner. Y-27632 also induced an increase in the production of reactive oxygen species (ROS). Pretreatment with N-acetylcysteine, an ROS scavenger, inhibited the ROS generation and neurite outgrowth in response to Y-27632. These results indicate that the activation of Rac1 and the generation of ROS contribute to the neurite outgrowth triggered by Y-27632 in PC12 cells.
Files in This Item:
T201606073.pdf Download
DOI
10.11620/IJOB.2016.41.4.231
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153068
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