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Reactive Oxygen Species are Involved in Y-27632-induced Neurite Outgrowth in PC12 Cells
DC Field | Value | Language |
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dc.contributor.author | 서정택 | - |
dc.date.accessioned | 2017-10-26T08:10:30Z | - |
dc.date.available | 2017-10-26T08:10:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1226-7155 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153068 | - |
dc.description.abstract | Inhibition of Rho-associated coiled coil-containing kinase (ROCK) has been reported to promote differentiation of neuronal cells. Here, we examined the effect of Y-27632, a ROCK inhibitor, on the outgrowth of neurites in PC12 cells. Y-27632 caused a rapid induction of neurite outgrowth in PC12 cells in a time-dependent manner. The neurite outgrowth, triggered by Y-27632, was accompanied by Rac1 activation, and was attenuated by Rac1 inhibitor NSC23766, in a concentration-dependent manner. Y-27632 also induced an increase in the production of reactive oxygen species (ROS). Pretreatment with N-acetylcysteine, an ROS scavenger, inhibited the ROS generation and neurite outgrowth in response to Y-27632. These results indicate that the activation of Rac1 and the generation of ROS contribute to the neurite outgrowth triggered by Y-27632 in PC12 cells. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Harn Rim Won Printing Co. | - |
dc.relation.isPartOf | International Journal of Oral Biology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Reactive Oxygen Species are Involved in Y-27632-induced Neurite Outgrowth in PC12 Cells | - |
dc.type | Article | - |
dc.publisher.location | Korea (South) | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Biology | - |
dc.contributor.googleauthor | So Yeong Park | - |
dc.contributor.googleauthor | Seong Ah Moon | - |
dc.contributor.googleauthor | Jeong Mi An | - |
dc.contributor.googleauthor | Du sik Kim | - |
dc.contributor.googleauthor | Jeong Taeg Seo | - |
dc.identifier.doi | 10.11620/IJOB.2016.41.4.231 | - |
dc.contributor.localId | A01905 | - |
dc.relation.journalcode | J01144 | - |
dc.contributor.alternativeName | Seo, Jeong Taeg | - |
dc.contributor.affiliatedAuthor | Seo, Jeong Taeg | - |
dc.citation.volume | 41 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 231 | - |
dc.citation.endPage | 236 | - |
dc.identifier.bibliographicCitation | International Journal of Oral Biology, Vol.41(4) : 231-236, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41072 | - |
dc.type.rims | ART | - |
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