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Clinical course of stage IV invasive mucinous adenocarcinoma of the lung

Authors
 Yoon Jin Cha  ;  Hye Ryun Kim  ;  Hye-Jeong Lee  ;  Byoung Chul Cho  ;  Hyo Sup Shim 
Citation
 Lung Cancer, Vol.102 : 82-88, 2016 
Journal Title
 Lung Cancer 
ISSN
 0169-5002 
Issue Date
2016
Abstract
INTRODUCTION: An invasive mucinous adenocarcinoma (IMA) is a distinct lung adenocarcinoma variant. The characteristics of stage IV IMAs are relatively unclear since most previous studies described resected cases from stage I to III. The present study aimed to investigate the clinical course of stage IV IMAs and compare the findings to those of stage IV invasive non-mucinous adenocarcinomas (INMAs). METHODS: The study included 36 IMA patients and 210 INMA patients. The clinicopathological parameters, treatment methods and responses, overall survival (OS), and progression-free survival (PFS) were evaluated. RESULTS: IMAs were predominantly located in the lower lobes and frequently presented with multifocal consolidation and lung-to-lung or pleural metastasis. KRAS mutations were noted in 60.0% of the examined IMAs. Non-TKI chemotherapy (CTx) was used in 72.2% of the IMA patients. OS was significantly better in untreated IMA patients than in untreated INMA patients. IMA patients treated with non-TKI CTx had no improvement of OS compared to the untreated IMA patients. However, among INMA patients, OS was best with TKIs in patients harbouring targetable mutations, followed by non-TKI CTx. IMA and INMA patients treated with non-TKI CTx had similar PFS. CONCLUSIONS: Stage IV IMAs have distinct clinicopathological characteristics, and they might be less aggressive than INMAs. Since non-TKI CTx might not be beneficial in IMA patients, new therapeutic approach is necessary.
Full Text
http://www.sciencedirect.com/science/article/pii/S0169500216305207?via%3Dihub
DOI
10.1016/j.lungcan.2016.11.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김혜련(Kim, Hye Ryun) ORCID logo https://orcid.org/0000-0002-1842-9070
심효섭(Shim, Hyo Sup) ORCID logo https://orcid.org/0000-0002-5718-3624
이혜정(Lee, Hye Jeong) ORCID logo https://orcid.org/0000-0003-4349-9174
조병철(Cho, Byoung Chul) ORCID logo https://orcid.org/0000-0002-5562-270X
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152824
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