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Interobserver and Test-Retest Reproducibility of T1ρ and T2 Measurements of Lumbar Intervertebral Discs by 3T Magnetic Resonance Imaging

 Yeon Hwa Yoo  ;  Choon-Sik Yoon  ;  Na Lae Eun  ;  Moon-jung Hwang  ;  Hanna Yoo  ;  Robert D. Peters  ;  Tae-Sub Chung  ;  Young Han Lee  ;  Jin-Suck Suh  ;  Sungjun Kim 
 KOREAN JOURNAL OF RADIOLOGY, Vol.17(6) : 903-911, 2016 
Journal Title
Issue Date
Adult ; Aged ; Female ; Humans ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc Degeneration/diagnosis* ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/pathology ; Lumbar Vertebrae/diagnostic imaging ; Magnetic Resonance Imaging* ; Male ; Middle Aged ; Nucleus Pulposus/diagnostic imaging ; Prospective Studies ; Reproducibility of Results ; Severity of Illness Index
Disc degeneration ; Intervertebral disc ; Magnetic resonance imaging ; Reproducibility ; T1 rho ; T2 mapping
OBJECTIVE: To investigate the interobserver and test-retest reproducibility of T1ρ and T2 measurements of lumbar intervertebral discs using 3T magnetic resonance imaging (MRI). MATERIALS AND METHODS: This study included a total of 51 volunteers (female, 26; male, 25; mean age, 54 ± 16.3 years) who underwent lumbar spine MRI with a 3.0 T scanner. Amongst these subjects, 40 underwent repeat T1ρ and T2 measurement acquisitions with identical image protocol. Two observers independently performed the region of interest measurements in the nuclei pulposi of the discs from L1-2 through L5-S1 levels. Statistical analysis was performed using intraclass correlation coefficient (ICC) with a two-way random model of absolute agreement. Comparison of the ICC values was done after acquisition of ICC values using Z test. Statistical significance was defined as p value < 0.05. RESULTS: The ICCs of interobserver reproducibility were 0.951 and 0.672 for T1ρ and T2 mapping, respectively. The ICCs of test-retest reproducibility (40 subjects) for T1ρ and T2 measurements were 0.922 and 0.617 for observer A and 0.914 and 0.628 for observer B, respectively. In the comparison of the aforementioned ICCs, ICCs of interobserver and test-retest reproducibility for T1ρ mapping were significantly higher than T2 mapping (p < 0.001). CONCLUSION: The interobserver and test-retest reproducibility of T1ρ mapping were significantly higher than those of T2 mapping for the quantitative assessment of nuclei pulposi of lumbar intervertebral discs.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sungjun(김성준) ORCID logo https://orcid.org/0000-0002-7876-7901
Suh, Jin Suck(서진석) ORCID logo https://orcid.org/0000-0001-9455-9240
Yoon, Choon Sik(윤춘식) ORCID logo https://orcid.org/0000-0003-2010-6710
Eun, Na Lae(은나래) ORCID logo https://orcid.org/0000-0002-7299-3051
Lee, Young Han(이영한) ORCID logo https://orcid.org/0000-0002-5602-391X
Chung, Tae Sub(정태섭)
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