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Altered tooth morphogenesis after silencing the planar cell polarity core component, Vangl2

Authors
 Zhaoming Wu  ;  Don Jeevanie Epasinghe  ;  Jinquan He  ;  Liwen Li  ;  David W. Green  ;  Min-Jung Lee  ;  Han-Sung Jung 
Citation
 CELL AND TISSUE RESEARCH, Vol.366(3) : 617-621, 2016 
Journal Title
CELL AND TISSUE RESEARCH
ISSN
 0302-766X 
Issue Date
2016
Abstract
Vangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis. After kidney transplantation of Vangl2 siRNA-treated tooth germs, teeth were observed to be small and malformed. We also show that Vangl2 is required to maintain the proper pattern of cell alignment in SEKs, which maybe important for the function of SEKs as signaling centers. These results suggest that Vangl2 plays an important role in the morphogenesis of teeth.
Full Text
https://link.springer.com/article/10.1007%2Fs00441-016-2489-4
DOI
10.1007/s00441-016-2489-4
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
David, William Green(데이비드 그린)
Jung, Han Sung(정한성) ORCID logo https://orcid.org/0000-0003-2795-531X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152683
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