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Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer

Authors
 Hae Won Kim  ;  Jie-Hyun Kim  ;  Beom Jin Lim  ;  HyunKi Kim  ;  Hoguen Kim  ;  Jae Jun Park  ;  Young Hoon Youn  ;  Hyojin Park  ;  Sung Hoon Noh  ;  Jong Won Kim  ;  Seung Ho Choi 
Citation
 Annals of Surgical Oncology, Vol.23(13) : 4344-4351, 2016 
Journal Title
 Annals of Surgical Oncology 
ISSN
 1068-9265 
Issue Date
2016
MeSH
Adenocarcinoma/metabolism ; Adenocarcinoma/pathology* ; Adenocarcinoma/surgery ; Adult ; Aged ; Carcinoma, Signet Ring Cell/metabolism ; Carcinoma, Signet Ring Cell/pathology* ; Carcinoma, Signet Ring Cell/surgery ; Estrogen Receptor alpha/metabolism ; Estrogen Receptor beta/metabolism ; Female ; Gastrectomy ; Humans ; Male ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness ; Prognosis ; Receptors, Androgen/metabolism ; Receptors, Progesterone/metabolism ; Retrospective Studies ; Sex Factors* ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology* ; Stomach Neoplasms/surgery ; Survival Rate
Keywords
Gastric Cancer ; Overall Survival ; Adrogen Receptor ; Gastric Cancer Tissue ; Signet Ring Cell Carcinoma
Abstract
BACKGROUND: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. METHODS: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. RESULTS: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. CONCLUSIONS: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.
Full Text
https://link.springer.com/article/10.1245%2Fs10434-016-5448-0
DOI
10.1245/s10434-016-5448-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
김종원(Kim, Jong Won)
김지현(Kim, Jie-Hyun) ORCID logo https://orcid.org/0000-0002-9198-3326
김현기(Kim, Hyunki) ORCID logo https://orcid.org/0000-0003-2292-5584
김호근(Kim, Ho Keun)
노성훈(Noh, Sung Hoon) ORCID logo https://orcid.org/0000-0003-4386-6886
박재준(Park, Jae Jun)
박효진(Park, Hyo Jin) ORCID logo https://orcid.org/0000-0003-4814-8330
윤영훈(Youn, Young Hoon) ORCID logo https://orcid.org/0000-0002-0071-229X
임범진(Lim, Beom Jin) ORCID logo https://orcid.org/0000-0003-2856-0133
최승호(Choi, Seung Ho) ORCID logo https://orcid.org/0000-0002-9872-3594
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152539
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