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Sex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer

DC FieldValueLanguage
dc.contributor.author김종원-
dc.contributor.author박재준-
dc.contributor.author박효진-
dc.contributor.author윤영훈-
dc.contributor.author임범진-
dc.contributor.author최승호-
dc.contributor.author김지현-
dc.contributor.author김현기-
dc.contributor.author김호근-
dc.contributor.author노성훈-
dc.date.accessioned2017-10-26T07:48:47Z-
dc.date.available2017-10-26T07:48:47Z-
dc.date.issued2016-
dc.identifier.issn1068-9265-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152539-
dc.description.abstractBACKGROUND: The overall incidence of gastric cancer (GC) is higher in males than females. Specifically, signet ring cell carcinoma (SRC) is more frequently observed in younger female patients. However, limited information focused on sex-specific differences in GC has been reported. The aim of our study was to analyze clinicopathological differences between sex groups to reveal sex disparities in GC. METHODS: We retrospectively analyzed 4722 patients with GC who underwent gastrectomy (females: 1586 (33.6 %); males: 3136 (66.4 %), and analyzed clinicopathological features between these sex groups. The overall survival (OS) rate was investigated between the two sex groups, with special reference to the pathologic World Health Organization GC classifications. Immunohistochemistry staining of sex hormone receptors, including the estrogen receptor (ER)-α, ER-β, progesterone receptor, and androgen receptor, was performed according to sex and pathological classification. RESULTS: Female patients were significantly associated with a younger age, poorly differentiated adenocarcinoma, and SRC compared with males. Female patients showed a significantly poorer OS than male patients, especially among those with advanced GC (AGC) aged ≤45 years. In females with AGC, those with SRC had a significantly poorer OS than those with other histologies. Moreover, the expression of ER-β was different between females and males with SRC. CONCLUSIONS: Females with GC were significantly younger and had a different SRC histology compared with males. Furthermore, females had significantly poorer prognostic factors among young patients with SRC. Thus, young female GC patients with SRC are a main target group in which to improve prognosis.-
dc.description.statementOfResponsibilityrestriction-
dc.publisherSpringer-
dc.relation.isPartOfAnnals of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Signet Ring Cell/metabolism-
dc.subject.MESHCarcinoma, Signet Ring Cell/pathology*-
dc.subject.MESHCarcinoma, Signet Ring Cell/surgery-
dc.subject.MESHEstrogen Receptor alpha/metabolism-
dc.subject.MESHEstrogen Receptor beta/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPrognosis-
dc.subject.MESHReceptors, Androgen/metabolism-
dc.subject.MESHReceptors, Progesterone/metabolism-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSex Factors*-
dc.subject.MESHStomach Neoplasms/metabolism-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery-
dc.subject.MESHSurvival Rate-
dc.titleSex Disparity in Gastric Cancer: Female Sex is a Poor Prognostic Factor for Advanced Gastric Cancer-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorHae Won Kim-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorBeom Jin Lim-
dc.contributor.googleauthorHyunKi Kim-
dc.contributor.googleauthorHoguen Kim-
dc.contributor.googleauthorJae Jun Park-
dc.contributor.googleauthorYoung Hoon Youn-
dc.contributor.googleauthorHyojin Park-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorSeung Ho Choi-
dc.identifier.doi10.1245/s10434-016-5448-0-
dc.contributor.localIdA01636-
dc.contributor.localIdA01774-
dc.contributor.localIdA02583-
dc.contributor.localIdA03363-
dc.contributor.localIdA04102-
dc.contributor.localIdA00996-
dc.contributor.localIdA01108-
dc.contributor.localIdA01183-
dc.contributor.localIdA01281-
dc.contributor.localIdA00925-
dc.relation.journalcodeJ00179-
dc.identifier.pmid27469120-
dc.identifier.urlhttps://link.springer.com/article/10.1245%2Fs10434-016-5448-0-
dc.subject.keywordGastric Cancer-
dc.subject.keywordOverall Survival-
dc.subject.keywordAdrogen Receptor-
dc.subject.keywordGastric Cancer Tissue-
dc.subject.keywordSignet Ring Cell Carcinoma-
dc.contributor.alternativeNameKim, Jong Won-
dc.contributor.alternativeNamePark, Jae Jun-
dc.contributor.alternativeNamePark, Hyo Jin-
dc.contributor.alternativeNameYoun, Young Hoon-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameChoi, Seung Ho-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.affiliatedAuthorPark, Jae Jun-
dc.contributor.affiliatedAuthorPark, Hyo Jin-
dc.contributor.affiliatedAuthorYoun, Young Hoon-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorChoi, Seung Ho-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Jong Won-
dc.citation.volume23-
dc.citation.number13-
dc.citation.startPage4344-
dc.citation.endPage4351-
dc.identifier.bibliographicCitationAnnals of Surgical Oncology, Vol.23(13) : 4344-4351, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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