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Anti-Sm is associated with the early poor outcome of lupus nephritis

Authors
 Sung Soo Ahn  ;  Byung-Woo Yoo  ;  Jason Jungsik Song  ;  Yong-Beom Park  ;  Soo-Kon Lee  ;  Sang-Won Lee 
Citation
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.19(9) : 897-902, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 
ISSN
 1756-1841 
Issue Date
2016
MeSH
Adolescent ; Adult ; Antibodies, Antinuclear/blood* ; Biomarkers/blood ; Biopsy ; Chi-Square Distribution ; Child ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney/drug effects ; Kidney/immunology* ; Kidney/pathology ; Kidney/physiopathology ; Logistic Models ; Lupus Nephritis/blood ; Lupus Nephritis/diagnosis ; Lupus Nephritis/drug therapy ; Lupus Nephritis/immunology* ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome ; Young Adult ; snRNP Core Proteins/immunology*
Keywords
anti-Sm ; immunosuppressants ; lupus nephritis ; outcome
Abstract
AIM: We investigated whether anti-Smith (Sm) is associated with the outcome of kidney biopsy-proven lupus nephritis. METHODS: We retrospectively analyzed clinical, laboratory and histological results in 90 patients with kidney biopsy-proven lupus nephritis. We defined persistent administration of immunosuppressants for more than 3 months after the kidney biopsy as early poor outcome of lupus nephritis. We compared baseline variables and delta values of lupus nephritis-related variables between patients with and without anti-Sm. The independent predictive values for early poor outcome were analyzed using logistic regression analysis. RESULTS: The median age was 32.0 years old, and 77 patients (85.5%) were women. Anti-Sm was found in 44 of 90 patients (48.8%). When we analyzed the differences in delta values of variables reflecting the kidney function or the early poor outcome between patients with and without anti-Sm, we found significant difference in the early poor outcome between the two groups (80.0% of patients having anti-Sm vs. 56.5% of those not having anti-Sm, P = 0.022). In multivariate logistic regression analysis, along with age and Systemic Lupus Erythematosus Disease Activity Index, the presence of anti-Sm increased the potential of the early poor outcome of lupus nephritis (odds ratio 2.870, 95% confidence interval, 1.033, 7.976, P = 0.043). CONCLUSION: Our data suggest that anti-Sm identified at kidney biopsy might have a predictive value for the early poor outcome of biopsy-proven lupus nephritis during the follow-up period.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12880/abstract
DOI
10.1111/1756-185X.12880
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Song, Jungsik Jason(송정식) ORCID logo https://orcid.org/0000-0003-0662-7704
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-9002-9880
Lee, Sang Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152504
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