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Anti-Sm is associated with the early poor outcome of lupus nephritis

DC Field Value Language
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.date.accessioned2017-10-26T07:46:37Z-
dc.date.available2017-10-26T07:46:37Z-
dc.date.issued2016-
dc.identifier.issn1756-1841-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152504-
dc.description.abstractAIM: We investigated whether anti-Smith (Sm) is associated with the outcome of kidney biopsy-proven lupus nephritis. METHODS: We retrospectively analyzed clinical, laboratory and histological results in 90 patients with kidney biopsy-proven lupus nephritis. We defined persistent administration of immunosuppressants for more than 3 months after the kidney biopsy as early poor outcome of lupus nephritis. We compared baseline variables and delta values of lupus nephritis-related variables between patients with and without anti-Sm. The independent predictive values for early poor outcome were analyzed using logistic regression analysis. RESULTS: The median age was 32.0 years old, and 77 patients (85.5%) were women. Anti-Sm was found in 44 of 90 patients (48.8%). When we analyzed the differences in delta values of variables reflecting the kidney function or the early poor outcome between patients with and without anti-Sm, we found significant difference in the early poor outcome between the two groups (80.0% of patients having anti-Sm vs. 56.5% of those not having anti-Sm, P = 0.022). In multivariate logistic regression analysis, along with age and Systemic Lupus Erythematosus Disease Activity Index, the presence of anti-Sm increased the potential of the early poor outcome of lupus nephritis (odds ratio 2.870, 95% confidence interval, 1.033, 7.976, P = 0.043). CONCLUSION: Our data suggest that anti-Sm identified at kidney biopsy might have a predictive value for the early poor outcome of biopsy-proven lupus nephritis during the follow-up period.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley on behalf of the Asia Pacific League of Associations for Rheumatology-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAntibodies, Antinuclear/blood*-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBiopsy-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHChild-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunosuppressive Agents/therapeutic use-
dc.subject.MESHKidney/drug effects-
dc.subject.MESHKidney/immunology*-
dc.subject.MESHKidney/pathology-
dc.subject.MESHKidney/physiopathology-
dc.subject.MESHLogistic Models-
dc.subject.MESHLupus Nephritis/blood-
dc.subject.MESHLupus Nephritis/diagnosis-
dc.subject.MESHLupus Nephritis/drug therapy-
dc.subject.MESHLupus Nephritis/immunology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHYoung Adult-
dc.subject.MESHsnRNP Core Proteins/immunology*-
dc.titleAnti-Sm is associated with the early poor outcome of lupus nephritis-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorByung-Woo Yoo-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSoo-Kon Lee-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1111/1756-185X.12880-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA01579-
dc.relation.journalcodeJ01158-
dc.identifier.eissn1756-185X-
dc.identifier.pmid27126359-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/1756-185X.12880/abstract-
dc.subject.keywordanti-Sm-
dc.subject.keywordimmunosuppressants-
dc.subject.keywordlupus nephritis-
dc.subject.keywordoutcome-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.citation.volume19-
dc.citation.number9-
dc.citation.startPage897-
dc.citation.endPage902-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, Vol.19(9) : 897-902, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48707-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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