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Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells

Authors
 Jong Youl Kim  ;  Joohyun Park  ;  Ji Young Chang  ;  Sa-Hyun Kim  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.25(5) : 241-251, 2016 
Journal Title
EXPERIMENTAL NEUROBIOLOGY
ISSN
 1226-2560 
Issue Date
2016
Keywords
glial cells ; inflammation ; ischemic stroke ; leukocytes
Abstract
The immune response after stroke is known to play a major role in ischemic brain pathobiology. The inflammatory signals released by immune mediators activated by brain injury sets off a complex series of biochemical and molecular events which have been increasingly recognized as a key contributor to neuronal cell death. The primary immune mediators involved are glial cells and infiltrating leukocytes, including neutrophils, monocytes and lymphocyte. After ischemic stroke, activation of glial cells and subsequent release of pro- and anti-inflammatory signals are important for modulating both neuronal cell damage and wound healing. Infiltrated leukocytes release inflammatory mediators into the site of the lesion, thereby exacerbating brain injury. This review describes how the roles of glial cells and circulating leukocytes are a double-edged sword for neuroinflammation by focusing on their detrimental and protective effects in ischemic stroke. Here, we will focus on underlying characterize of glial cells and leukocytes under inflammation after ischemic stroke.
Files in This Item:
T201604454.pdf Download
DOI
10.5607/en.2016.25.5.241
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Park, Joohyun(박주현) ORCID logo https://orcid.org/0000-0002-0897-4665
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152463
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