Spinal cord involvement in Behçet’s disease

Cited 26 times in

Authors: Hyung Seok Lee ; Do Young Kim ; Ha Young Shin ; Young-Chul Choi ; Seung Min Kim

MeSH: Adult ; Behcet Syndrome/complications* ; Behcet Syndrome/diagnostic imaging ; Biomarkers/cerebrospinal fluid ; Disability Evaluation ; Disease Progression ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Myelitis, Transverse/cerebrospinal fluid ; Myelitis, Transverse/diagnostic imaging ; Myelitis, Transverse/drug therapy ; Myelitis, Transverse/etiology* ; Registries ; Retrospective Studies ; Spinal Cord*/diagnostic imaging ; Spinal Cord*/drug effects ; Spinal Cord*/metabolism ; Treatment Outcome ; Young Adult

Keywords: Behçet’s disease ; longitudinally extensive transverse myelitis ; neuro-Behçet’s disease ; neuromyelitis optica ; serum anti-aquaporin-4 antibody ; spinal cord

Abstract: BACKGROUND: Spinal cord involvement in Beh?et's disease is not well studied.

OBJECTIVE: To evaluate the clinical, laboratory and magnetic resonance imaging characteristics of spinal cord involvement in Beh?et's disease.

METHODS: We retrospectively reviewed 10 spinal cord involvements in seven patients with Beh?et's disease.

RESULTS: The median age of onset for spinal cord involvement was 32 (23-45 years). Two patients showed a secondary progressive course. Cerebrospinal fluid findings revealed mild to moderate pleocytosis and/or elevated protein levels. In eight spinal cord involvements, the lesion was longer than three vertebrae. Serum anti-aquaporin-4 antibody was negative in all four patients tested.

CONCLUSIONS: Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Beh?et's disease.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

Yonsei Authors: Kim, Do Young(김도영) https://orcid.org/0000-0002-0194-9854
Kim, Seung Min(김승민) https://orcid.org/0000-0002-4384-9640
Park, Hyung Jun(박형준)
Shin, Ha Young(신하영) https://orcid.org/0000-0002-4408-8265
Lee, Hyung Seok(이형석)
Choi, Young Chul(최영철) https://orcid.org/0000-0001-5525-6861

Show full item record Find it @ YMLIB

YUHSpace: Spinal cord involvement in Behçet’s disease