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Mechanisms of epidermal growth factor receptor tyrosine kinase inhibitor resistance and strategies to overcome resistance in lung adenocarcinoma

Authors
 Yoon Soo Chang  ;  Chang-Min Choi  ;  Jae Cheol Lee 
Citation
 Tuberculosis and Respiratory Diseases, Vol.79(4) : 248-256, 2016 
Journal Title
 Tuberculosis and Respiratory Diseases 
ISSN
 1738-3536 
Issue Date
2016
Keywords
Adenocarcinoma of Lung ; Drug Resistance ; Genes, erbB-1 ; Receptor, Epidermal Growth Factor
Abstract
Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.
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DOI
10.4046/trd.2016.79.4.248
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152448
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