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Mechanisms of epidermal growth factor receptor tyrosine kinase inhibitor resistance and strategies to overcome resistance in lung adenocarcinoma

DC FieldValueLanguage
dc.contributor.author장윤수-
dc.date.accessioned2017-10-26T07:44:14Z-
dc.date.available2017-10-26T07:44:14Z-
dc.date.issued2016-
dc.identifier.issn1738-3536-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152448-
dc.description.abstractSomatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한결핵 및 호흡기학회-
dc.relation.isPartOfTuberculosis and Respiratory Diseases-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMechanisms of epidermal growth factor receptor tyrosine kinase inhibitor resistance and strategies to overcome resistance in lung adenocarcinoma-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYoon Soo Chang-
dc.contributor.googleauthorChang-Min Choi-
dc.contributor.googleauthorJae Cheol Lee-
dc.identifier.doi10.4046/trd.2016.79.4.248-
dc.contributor.localIdA03456-
dc.relation.journalcodeJ02761-
dc.relation.journalsince2004~-
dc.identifier.pmid27790276-
dc.relation.journalbefore~2004 Tuberculosis and Respiratory Diseases (결핵 및 호흡기질환)-
dc.subject.keywordAdenocarcinoma of Lung-
dc.subject.keywordDrug Resistance-
dc.subject.keywordGenes, erbB-1-
dc.subject.keywordReceptor, Epidermal Growth Factor-
dc.contributor.alternativeNameChang, Yoon Soo-
dc.contributor.affiliatedAuthorChang, Yoon Soo-
dc.citation.volume79-
dc.citation.number4-
dc.citation.startPage248-
dc.citation.endPage256-
dc.identifier.bibliographicCitationTuberculosis and Respiratory Diseases, Vol.79(4) : 248-256, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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