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Magnetization-tagged MRI is a simple method for predicting liver fibrosis

 Kyung-Eun Kim  ;  Mi-Suk Park  ;  Sohae Chung  ;  Chansik An  ;  Leon Axel  ;  Rakhmonova Gulbahor Ergashovna 
 Clinical and Molecular Hepatology, Vol.22(1) : 140-145, 2016 
Journal Title
 Clinical and Molecular Hepatology 
Issue Date
Aged ; Aspartate Aminotransferases/analysis ; Blood Platelets/cytology ; Humans ; Liver Cirrhosis/diagnostic imaging* ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/pathology ; Magnetic Resonance Imaging* ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index
Fibrosis ; Liver cirrhosis ; Magnetic resonance imaging
BACKGROUND/AIMS: To assess the usefulness of magnetization-tagged magnetic resonance imaging (MRI) in quantifying cardiac-induced liver motion and deformation in order to predict liver fibrosis. METHODS: This retrospective study included 85 patients who underwent liver MRI including magnetization-tagged sequences from April 2010 to August 2010. Tagged images were acquired in three coronal and three sagittal planes encompassing both the liver and heart. A Gabor filter bank was used to measure the maximum value of displacement (MaxDisp) and the maximum and minimum values of principal strains (MaxP1 and MinP2, respectively). Patients were divided into three groups (no fibrosis, mild-to-moderate fibrosis, and significant fibrosis) based on their aspartate-aminotransferase-to-platelet ratio index (APRI) score. Group comparisons were made using ANOVA tests. RESULTS: The patients were divided into three groups according to APRI scores: no fibrosis (≤ 0.5; n=41), moderate fibrosis (0.5-1.5; n=23), and significant fibrosis (>1.5; n=21). The values of MaxDisp were 2.9 ± 0.9 (mean ± SD), 2.3 ± 0.7, and 2.1 ± 0.6 in the no fibrosis, moderate fibrosis, and significant fibrosis groups, respectively (P<0.001); the corresponding values of MaxP1 were 0.05 ± 0.2, 0.04 ± 0.02, and 0.03 ± 0.01, respectively (P=0.002), while those of MinP2 were -0.07 ± 0.02, -0.05 ± 0.02, and -0.04 ± 0.01, respectively (P<0.001). CONCLUSIONS: Tagge d MRI to quantify cardiac-induced liver motion can be easily incorporated in routine liver MRI and may represent a helpful complementary tool in the diagnosis of early liver fibrosis.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
김경은(Kim, Kyung Eun)
박미숙(Park, Mi-Suk) ORCID logo https://orcid.org/0000-0001-5817-2444
안찬식(An, Chansik) ORCID logo https://orcid.org/0000-0002-0484-6658
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