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In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats

Authors
 Jeongsoo Han  ;  Myeounghoon Cha  ;  Minjee Kwon  ;  Seong-Karp Hong  ;  Sun Joon Bai  ;  Bae Hwan Lee 
Citation
 NEUROSCIENCE LETTERS, Vol.634 : 146-152, 2016 
Journal Title
 NEUROSCIENCE LETTERS 
ISSN
 0304-3940 
Issue Date
2016
MeSH
Animals ; Cerebral Cortex/diagnostic imaging* ; Cerebral Cortex/physiopathology ; Hyperalgesia/physiopathology ; Male ; Neuralgia/physiopathology ; Neuronal Plasticity ; Rats, Sprague-Dawley ; Sciatic Nerve/injuries* ; Voltage-Sensitive Dye Imaging
Keywords
Insular cortex ; Nerve injury ; Neuropathic pain ; Neuroplasticity ; Optical imaging ; Voltage-sensitive dye
Abstract
The insular cortex (IC) is a pain-related brain region that receives various types of sensory input and processes the emotional aspects of pain. The present study was conducted to investigate spatiotemporal patterns related to neuroplastic changes in the IC after nerve injury using voltage-sensitive dye imaging. The tibial and sural nerves of rats were injured under pentobarbital anesthesia. To observe optical signals in the IC, rats were re-anesthetized with urethane 7days after injury, and a craniectomy was performed to allow for optical imaging. Optical signals of the IC were elicited by peripheral electrical stimulation. Neuropathic rats showed a significantly higher optical intensity following 5.0mA electrical stimulation compared to sham-injured rats. A larger area of activation was observed by 1.25 and 2.5mA electrical stimulation compared to sham-injured rats. The activated areas tended to be larger, and the peak amplitudes of optical signals increased with increasing stimulation intensity in both groups. These results suggest that the elevated responsiveness of the IC to peripheral stimulation is related to neuropathic pain, and that neuroplastic changes are likely to be involved in the IC after nerve injury.
Full Text
http://www.sciencedirect.com/science/article/pii/S0304394016307595?via%3Dihub
DOI
10.1016/j.neulet.2016.10.015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
Cha, Myeoung Hoon(차명훈) ORCID logo https://orcid.org/0000-0002-7993-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152364
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