Cited 11 times in
In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats
DC Field | Value | Language |
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dc.contributor.author | 배선준 | - |
dc.contributor.author | 이배환 | - |
dc.contributor.author | 차명훈 | - |
dc.date.accessioned | 2017-10-26T07:40:33Z | - |
dc.date.available | 2017-10-26T07:40:33Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152364 | - |
dc.description.abstract | The insular cortex (IC) is a pain-related brain region that receives various types of sensory input and processes the emotional aspects of pain. The present study was conducted to investigate spatiotemporal patterns related to neuroplastic changes in the IC after nerve injury using voltage-sensitive dye imaging. The tibial and sural nerves of rats were injured under pentobarbital anesthesia. To observe optical signals in the IC, rats were re-anesthetized with urethane 7days after injury, and a craniectomy was performed to allow for optical imaging. Optical signals of the IC were elicited by peripheral electrical stimulation. Neuropathic rats showed a significantly higher optical intensity following 5.0mA electrical stimulation compared to sham-injured rats. A larger area of activation was observed by 1.25 and 2.5mA electrical stimulation compared to sham-injured rats. The activated areas tended to be larger, and the peak amplitudes of optical signals increased with increasing stimulation intensity in both groups. These results suggest that the elevated responsiveness of the IC to peripheral stimulation is related to neuropathic pain, and that neuroplastic changes are likely to be involved in the IC after nerve injury. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Scientific Publishers Ireland | - |
dc.relation.isPartOf | NEUROSCIENCE LETTERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cerebral Cortex/diagnostic imaging* | - |
dc.subject.MESH | Cerebral Cortex/physiopathology | - |
dc.subject.MESH | Hyperalgesia/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Neuralgia/physiopathology | - |
dc.subject.MESH | Neuronal Plasticity | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Sciatic Nerve/injuries* | - |
dc.subject.MESH | Voltage-Sensitive Dye Imaging | - |
dc.title | In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats | - |
dc.type | Article | - |
dc.publisher.location | Ireland | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Jeongsoo Han | - |
dc.contributor.googleauthor | Myeounghoon Cha | - |
dc.contributor.googleauthor | Minjee Kwon | - |
dc.contributor.googleauthor | Seong-Karp Hong | - |
dc.contributor.googleauthor | Sun Joon Bai | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.identifier.doi | 10.1016/j.neulet.2016.10.015 | - |
dc.contributor.localId | A02791 | - |
dc.contributor.localId | A03994 | - |
dc.contributor.localId | A01795 | - |
dc.relation.journalcode | J02364 | - |
dc.identifier.eissn | 1872-7972 | - |
dc.identifier.pmid | 27737808 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0304394016307595?via%3Dihub | - |
dc.subject.keyword | Insular cortex | - |
dc.subject.keyword | Nerve injury | - |
dc.subject.keyword | Neuropathic pain | - |
dc.subject.keyword | Neuroplasticity | - |
dc.subject.keyword | Optical imaging | - |
dc.subject.keyword | Voltage-sensitive dye | - |
dc.contributor.alternativeName | Bai, Sun Joon | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.alternativeName | Cha, Myeoung Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Cha, Myeoung Hoon | - |
dc.contributor.affiliatedAuthor | Bai, Sun Joon | - |
dc.citation.volume | 634 | - |
dc.citation.startPage | 146 | - |
dc.citation.endPage | 152 | - |
dc.identifier.bibliographicCitation | NEUROSCIENCE LETTERS, Vol.634 : 146-152, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48097 | - |
dc.type.rims | ART | - |
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