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Posterior Ventricular Enlargement to Differentiate Dementia with Lewy Bodies from Alzheimer's Disease

 Ye, Byoung Seok  ;  Lee, Yoonju  ;  Kwak, Kichang  ;  Park, Yeong-Hun  ;  Ham, Jee Hyun  ;  Lee, Jae Jung  ;  Shin, Na-Young  ;  Lee, Jong-Min  ;  Sohn, Young H.  ;  Lee, Phil Hyu 
 JOURNAL OF ALZHEIMERS DISEASE, Vol.52(4) : 1237-1243, 2016 
Journal Title
Issue Date
Aged ; Alzheimer Disease/diagnosis* ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Female ; Humans ; Lateral Ventricles/diagnostic imaging ; Lateral Ventricles/pathology* ; Lewy Body Disease/diagnosis* ; Lewy Body Disease/diagnostic imaging ; Lewy Body Disease/pathology ; Magnetic Resonance Imaging ; Male ; Neuroimaging ; Neuropsychological Tests ; Occipital Lobe/diagnostic imaging ; Occipital Lobe/pathology ; Temporal Lobe/diagnostic imaging ; Temporal Lobe/pathology
Alzheimer’s disease ; dementia with Lewy bodies ; ventricular enlargement
BACKGROUND: Enlargement of the lateral ventricle is observed in dementia associated with Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). OBJECTIVE: The degree of anteroposterior ventricular enlargement and its correlation with clinical and neuropsychological features were investigated in DLB patients. METHODS: Forty-eight patients with DLB, 76 with AD, and 45 subjects with normal cognition (NC) underwent structural brain MRI and detailed neuropsychological tests. Ventricular shape was compared among the groups by visual inspection. Posterior ventricle enlargement (PVE) was defined as the ratio of the distance between the temporal and occipital horns of the lateral ventricle to the distance between the temporal horn of the lateral ventricle and occipital pole of the brain. RESULTS: After controlling for age, sex, and education, higher PVE was observed in the DLB group than in the AD group (68.5 ± 7.9% versus 62.8 ± 9.0%, respectively; p?=?0.001) or the NC group (61.9 ± 9.9%, p?=?0.002). However, higher PVE was not associated with poorer neuropsychological performance, nor was it associated with any clinical features in the DLB group after controlling for age, sex, and education. CONCLUSION: PVE occurs more often in DLB than in AD and NC. However, it is unclear how PVE is related to the clinical and neuropsychological features of DLB.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Lee, Yoon Ju(이윤주)
Lee, Jae Jung(이재정)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Ham, Jee Hyun(함지현)
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