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Expression of glutamine metabolism-related proteins in thyroid cancer

 Hye Min Kim  ;  Yu Kyung Lee  ;  Ja Seung Koo 
 ONCOTARGET , Vol.7(33) : 53628-53641, 2016 
Journal Title
Issue Date
Adult ; Aged ; Amino Acid Transport System ASC/biosynthesis ; Female ; Glutaminase/biosynthesis* ; Glutamine/metabolism* ; Humans ; Male ; Middle Aged ; Minor Histocompatibility Antigens/biosynthesis ; Sugar Alcohol Dehydrogenases/biosynthesis* ; Thyroid Neoplasms/metabolism*
glutamine ; metabolism ; pathology ; stroma ; thyroid cancer
PURPOSE: This study aimed to investigate the expression of glutamine metabolism-related protein in tumor and stromal compartments among the histologic subtypes of thyroid cancer. RESULTS: GLS1 and GDH expression in tumor and stromal compartments were the highest in AC than in other subtypes. Tumoral ASCT2 expression was higher in MC but lower in FC (p < 0.001). In PTC, tumoral GLS1 and tumoral GDH expression was higher in the conventional type than in the follicular variant (p = 0.043 and 0.001, respectively), and in PTC with BRAF V600E mutation than in PTC without BRAF V600E mutation (p<0.001). Stromal GDH positivity was the independent factor associated with short overall survival (hazard ratio: 21.48, 95% confidence interval: 2.178-211.8, p = 0.009). METHODS: We performed tissue microarrays with 557 thyroid cancer cases (papillary thyroid carcinoma [PTC]: 344, follicular carcinoma [FC]: 112, medullary carcinoma [MC]: 70, poorly differentiated carcinoma [PDC]: 23, and anaplastic carcinoma [AC]: 8) and 152 follicular adenoma (FA) cases. We performed immunohistochemical staining of glutaminolysis-related proteins (glutaminase 1 [GLS1], glutamate dehydrogenase [GDH], and amino acid transporter-2 [ASCT-2]). CONCLUSION: Glutamine metabolism-related protein expression differed among the histologic subtypes of thyroid cancer.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
Lee, Yu Kyung(이유경)
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