Cited 25 times in
Expression of glutamine metabolism-related proteins in thyroid cancer
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.contributor.author | 이유경 | - |
dc.date.accessioned | 2017-10-26T07:36:16Z | - |
dc.date.available | 2017-10-26T07:36:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152259 | - |
dc.description.abstract | PURPOSE: This study aimed to investigate the expression of glutamine metabolism-related protein in tumor and stromal compartments among the histologic subtypes of thyroid cancer. RESULTS: GLS1 and GDH expression in tumor and stromal compartments were the highest in AC than in other subtypes. Tumoral ASCT2 expression was higher in MC but lower in FC (p < 0.001). In PTC, tumoral GLS1 and tumoral GDH expression was higher in the conventional type than in the follicular variant (p = 0.043 and 0.001, respectively), and in PTC with BRAF V600E mutation than in PTC without BRAF V600E mutation (p<0.001). Stromal GDH positivity was the independent factor associated with short overall survival (hazard ratio: 21.48, 95% confidence interval: 2.178-211.8, p = 0.009). METHODS: We performed tissue microarrays with 557 thyroid cancer cases (papillary thyroid carcinoma [PTC]: 344, follicular carcinoma [FC]: 112, medullary carcinoma [MC]: 70, poorly differentiated carcinoma [PDC]: 23, and anaplastic carcinoma [AC]: 8) and 152 follicular adenoma (FA) cases. We performed immunohistochemical staining of glutaminolysis-related proteins (glutaminase 1 [GLS1], glutamate dehydrogenase [GDH], and amino acid transporter-2 [ASCT-2]). CONCLUSION: Glutamine metabolism-related protein expression differed among the histologic subtypes of thyroid cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Amino Acid Transport System ASC/biosynthesis | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glutaminase/biosynthesis* | - |
dc.subject.MESH | Glutamine/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Minor Histocompatibility Antigens/biosynthesis | - |
dc.subject.MESH | Sugar Alcohol Dehydrogenases/biosynthesis* | - |
dc.subject.MESH | Thyroid Neoplasms/metabolism* | - |
dc.title | Expression of glutamine metabolism-related proteins in thyroid cancer | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Yu Kyung Lee | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.18632/oncotarget.10682 | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A03010 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27447554 | - |
dc.subject.keyword | glutamine | - |
dc.subject.keyword | metabolism | - |
dc.subject.keyword | pathology | - |
dc.subject.keyword | stroma | - |
dc.subject.keyword | thyroid cancer | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.alternativeName | Lee, Yu Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Lee, Yu Kyung | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 33 | - |
dc.citation.startPage | 53628 | - |
dc.citation.endPage | 53641 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.7(33) : 53628-53641, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 47995 | - |
dc.type.rims | ART | - |
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