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The change of hippocampal volume and its relevance with inner ear function in Meniere's disease patients

Authors
 Young Joon Seo  ;  Jinna Kim  ;  Sung Huhn Kim 
Citation
 AURIS NASUS LARYNX, Vol.43(6) : 620-625, 2016 
Journal Title
 AURIS NASUS LARYNX 
ISSN
 0385-8146 
Issue Date
2016
MeSH
Adult ; Audiometry, Pure-Tone ; Caloric Tests ; Case-Control Studies ; Disease Progression ; Female ; Hippocampus/diagnostic imaging* ; Hippocampus/pathology ; Humans ; Magnetic Resonance Imaging ; Male ; Meniere Disease/diagnostic imaging* ; Meniere Disease/physiopathology ; Middle Aged ; Organ Size ; Retrospective Studies ; Vestibular Evoked Myogenic Potentials ; Vestibular Function Tests
Keywords
Glucocorticoid hormon ; Hippocampus ; MRI ; Meniere's disease
Abstract
OBJECTIVES: To reveal the relationship between the disease progression and the hippocampal volume in Meniere's disease, which may indirectly reflect the degree of patients' chronic exposure to stress. METHODS: Retrospective review of medical records and brain magnetic resonance image (MRI) of Meniere's disease patients and healthy controls from 2008 to 2013. Age- and sex-matched consecutive 38 definite Meniere's disease patients and 76 healthy controls where brain MRIs, hearing, and vestibular function tests were available. We divided the patients into normal and abnormal groups according to the results functional tests such as pure tone audiometry (PTA), vestibular evoked myogenic potential (VEMP), and bithermal caloric test. RESULTS: Absolute hippocampal volume of Meniere's disease patients was significantly smaller than that of controls (3.33±0.84cm(3) for left side vs. 3.82±0.37cm(3) for right side, p<0.001). Mean left hippocampal volume of patients with abnormal VEMP and bithermal caloric test on lesion side was significantly smaller than that of the patients with the normal test result (all p<0.05). Average hearing thresholds of the patients showed strong correlation with left hippocampal volumes (p-value<0.001). Those with decreased left hippocampal volume were also more likely to experience augmented emotional stress reactivity. CONCLUSION: Meniere's disease patients had significantly decreased hippocampal volume and the volume was significantly correlated with severity of hearing and vestibular function of affected side. This may represent that Meniere's disease patients are exposed to chronic stress for unpredictable vertigo and hearing fluctuation, which finally cause hippocampus atrophy.
Full Text
http://www.sciencedirect.com/science/article/pii/S0385814616300293
DOI
10.1016/j.anl.2016.01.006
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Huhn(김성헌)
Kim, Jinna(김진아) ORCID logo https://orcid.org/0000-0002-9978-4356
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152219
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