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Acceleration of osteogenesis by platelet-rich plasma with acellular dermal matrix in a calvarial defect model

Authors
 Woon Hyeok Jeong  ;  Tai Suk Roh  ;  Young Seok Kim  ;  Eun Hye Kang  ;  Bok Ki Jung  ;  Won Jai Lee  ;  Dae Hyun Lew  ;  In Sik Yun 
Citation
 CHILDS NERVOUS SYSTEM, Vol.32(9) : 1653-1659, 2016 
Journal Title
CHILDS NERVOUS SYSTEM
ISSN
 0256-7040 
Issue Date
2016
MeSH
Acellular Dermis* ; Animals ; Disease Models, Animal* ; Humans ; Osteogenesis/physiology* ; Pilot Projects ; Platelet-Rich Plasma/physiology* ; Rabbits ; Random Allocation ; Skull/diagnostic imaging* ; Skull/physiology* ; Skull/surgery
Keywords
Acellular dermis ; Bone healing ; Platelet ; Skull
Abstract
PURPOSE: The effects of platelet-rich plasma (PRP) on improvement of bone regeneration have been widely investigated. However, use of a proper scaffold is also important to the delivery of bioactive materials. The aim of this study was to analyze the effects of PRP with acellular dermal matrix (ADM) as a bone substitute in a cranial defect model.

METHODS: Twenty-nine New Zealand white rabbits were randomly divided into four groups including control, PRP, ADM, and PRP with ADM. A 15 × 15-mm(2) bony defect was carefully created in the cranium. The experimental materials were applied in each group. After 16 weeks, the volume and surface area of new bone were measured using three-dimensional computed tomography and digital photography, and the new bone was analyzed histologically.

RESULTS: The PRP with ADM group exhibited a statistically significant increase in volume and surface area of newly formed bone compared with the other groups (p < 0.05). Histological findings revealed compact lamellar bone in the PRP with ADM group. In contrast, scattered bone islands were detected within the fibrous connective tissue in the other groups.

CONCLUSIONS: The regeneration of mature and augmented bone was achieved following the application of PRP mixed with ADM. The results indicated that the PRP combined with ADM could be a potentially useful substitute for bone and may aid in the elimination of additional donor-site harvest procedures.
Full Text
https://link.springer.com/article/10.1007%2Fs00381-016-3150-y
DOI
10.1007/s00381-016-3150-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Young Seok(김영석) ORCID logo https://orcid.org/0000-0002-0981-2107
Roh, Tai Suk(노태석) ORCID logo https://orcid.org/0000-0001-8681-159X
Lew, Dae Hyun(유대현)
Yun, In Sik(윤인식) ORCID logo https://orcid.org/0000-0003-1103-7047
Lee, Won Jai(이원재) ORCID logo https://orcid.org/0000-0003-3056-0503
Jung, Bok Ki(정복기) ORCID logo https://orcid.org/0000-0002-4347-560X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152040
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