0 75

Cited 5 times in

STAT3-induced WDR1 overexpression promotes breast cancer cell migration

Authors
 Joo Hyun Lee  ;  Ji Eun Kim  ;  Baek Gil Kim  ;  Hyun Ho Han  ;  Suki Kang  ;  Nam Hoon Cho 
Citation
 Cellular Signalling, Vol.28(11) : 1753-1760, 2016 
Journal Title
 Cellular Signalling 
ISSN
 0898-6568 
Issue Date
2016
MeSH
Breast Neoplasms/genetics ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology* ; Cell Line, Tumor ; Cell Movement* ; Female ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; Humans ; Microfilament Proteins/genetics ; Microfilament Proteins/metabolism* ; Neoplasm Invasiveness ; Promoter Regions, Genetic/genetics ; Protein Binding ; STAT3 Transcription Factor/metabolism* ; Survival Analysis ; Up-Regulation
Keywords
Breast cancer ; Cell migration ; Promoter binding ; STAT3 ; Transcription factor ; WDR1 (AIP1)
Abstract
WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.
Full Text
http://www.sciencedirect.com/science/article/pii/S0898656816302042?via%3Dihub
DOI
10.1016/j.cellsig.2016.08.006
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
강숙희(Kang, Suki) ORCID logo https://orcid.org/0000-0002-9957-3479
김백길(Kim, Baek Gil) ORCID logo https://orcid.org/0000-0001-6270-1433
조남훈(Cho, Nam Hoon) ORCID logo https://orcid.org/0000-0002-0045-6441
한현호(Han, Hyun Ho) ORCID logo https://orcid.org/0000-0002-6268-0860
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152028
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse