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STAT3-induced WDR1 overexpression promotes breast cancer cell migration

DC Field Value Language
dc.contributor.author강숙희-
dc.contributor.author김백길-
dc.contributor.author조남훈-
dc.contributor.author한현호-
dc.date.accessioned2017-10-26T07:26:20Z-
dc.date.available2017-10-26T07:26:20Z-
dc.date.issued2016-
dc.identifier.issn0898-6568-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152028-
dc.description.abstractWD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science Ltd-
dc.relation.isPartOfCELLULAR SIGNALLING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/genetics-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement*-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHEK293 Cells-
dc.subject.MESHHumans-
dc.subject.MESHMicrofilament Proteins/genetics-
dc.subject.MESHMicrofilament Proteins/metabolism*-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPromoter Regions, Genetic/genetics-
dc.subject.MESHProtein Binding-
dc.subject.MESHSTAT3 Transcription Factor/metabolism*-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHUp-Regulation-
dc.titleSTAT3-induced WDR1 overexpression promotes breast cancer cell migration-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorJoo Hyun Lee-
dc.contributor.googleauthorJi Eun Kim-
dc.contributor.googleauthorBaek Gil Kim-
dc.contributor.googleauthorHyun Ho Han-
dc.contributor.googleauthorSuki Kang-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi10.1016/j.cellsig.2016.08.006-
dc.contributor.localIdA00484-
dc.contributor.localIdA03812-
dc.contributor.localIdA00044-
dc.relation.journalcodeJ00502-
dc.identifier.eissn1873-3913-
dc.identifier.pmid27521604-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0898656816302042?via%3Dihub-
dc.subject.keywordBreast cancer-
dc.subject.keywordCell migration-
dc.subject.keywordPromoter binding-
dc.subject.keywordSTAT3-
dc.subject.keywordTranscription factor-
dc.subject.keywordWDR1 (AIP1)-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameKim, Baek Gil-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorKim, Baek Gil-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorKang, Suki-
dc.citation.volume28-
dc.citation.number11-
dc.citation.startPage1753-
dc.citation.endPage1760-
dc.identifier.bibliographicCitationCELLULAR SIGNALLING, Vol.28(11) : 1753-1760, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46350-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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