75 101

Cited 14 times in

Mechanosensory neurons control sweet sensing in Drosophila

Authors
 Yong Taek Jeong  ;  Soo Min Oh  ;  Jaewon Shim  ;  Jeong Taeg Seo  ;  Jae Young Kwon  ;  Seok Jun Moon 
Citation
 NATURE COMMUNICATIONS, Vol.7 : 12872, 2016 
Journal Title
 NATURE COMMUNICATIONS 
Issue Date
2016
MeSH
Adolescent ; Alleles ; Child ; Child, Preschool ; Ciliopathies/diagnosis ; Ciliopathies/genetics* ; Exome* ; Female ; Genetic Heterogeneity ; Humans ; Infant ; Kidney Diseases, Cystic/diagnosis ; Kidney Diseases, Cystic/genetics* ; Male ; Mutation ; Sequence Analysis, DNA/methods
Abstract
Animals discriminate nutritious food from toxic substances using their sense of taste. Since taste perception requires taste receptor cells to come into contact with water-soluble chemicals, it is a form of contact chemosensation. Concurrent with that contact, mechanosensitive cells detect the texture of food and also contribute to the regulation of feeding. Little is known, however, about the extent to which chemosensitive and mechanosensitive circuits interact. Here, we show Drosophila prefers soft food at the expense of sweetness and that this preference requires labellar mechanosensory neurons (MNs) and the mechanosensory channel Nanchung. Activation of these labellar MNs causes GABAergic inhibition of sweet-sensing gustatory receptor neurons, reducing the perceived intensity of a sweet stimulus. These findings expand our understanding of the ways different sensory modalities cooperate to shape animal behaviour.
Files in This Item:
T201603521.pdf Download
DOI
10.1038/ncomms12872
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
Jeong, Yong Taek(정용택) ORCID logo https://orcid.org/0000-0003-0067-6396
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152009
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse