99 158

Cited 2 times in

Different Responses in Induction of Allergen Specific Immunoglobulin G4 and IgE-Blocking Factors for Three Mite Subcutaneous Immunotherapy Products

Authors
 Kyung Hee Park  ;  Sang Chul Lee  ;  Young Woong Son  ;  Kyoung Yong Jeong  ;  Yoo Seob Shin  ;  Jung U Shin  ;  Da Woon Sim  ;  Hye Jung Park  ;  Jae-Hyun Lee  ;  Kwang Hoon Lee  ;  Jung-Won Park 
Citation
 Yonsei Medical Journal, Vol.57(6) : 1427-1434, 2016 
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Issue Date
2016
MeSH
Adult ; Allergens/administration & dosage ; Allergens/immunology* ; Animals ; Antibody Specificity/immunology ; Antigens, Dermatophagoides ; Antigens, Neoplasm* ; Dermatitis, Atopic/blood ; Dermatitis, Atopic/immunology* ; Dermatitis, Atopic/therapy* ; Desensitization, Immunologic/methods* ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Immunoglobulin E/blood ; Immunoglobulin E/immunology* ; Immunoglobulin G/blood ; Immunoglobulin G/immunology* ; Injections, Subcutaneous ; Male ; Mites/immunology* ; Pyroglyphidae/immunology ; Treatment Outcome ; Young Adult
Keywords
Blocking factor ; IgG4 ; house dust mite ; immunotherapy ; specific IgE
Abstract
PURPOSE: Specific immunoglobulin G4 (sIgG4) and immunoglobulin E (IgE)-blocking factors produced by subcutaneous immunotherapy (SCIT) play a critical role in the induction of allergen tolerance. However, comparative studies of available SCIT reagents on the induction of sIgG4 are limited. We compared increases in sIgG4 for three different house dust mite (HDM) SCIT reagents. MATERIALS AND METHODS: Seventy-two HDM sensitized allergic patients were enrolled and classified into four groups: 1) control (n=27), 2) SCIT with Hollister-Stier® (n=19), 3) Tyrosine S® (n=16), and 4) Novo-Helisen® (n=10). Levels of specific IgE (sIgE), sIgG4, and IgE blocking factor to Dermatophagoides farinae (D. farinae) were measured using ImmunoCAP (sIgE, sIgG4) and enzyme-linked immunosorbent assay (ELISA) (IgE-blocking factors). Levels were measured before and 13.9±6.6 months after the SCIT. The allergen specificity and the induction levels of sIgE and sIgG4 were confirmed by immunoblot analysis. RESULTS: After SCIT, sIgG4 levels to D. farinae increased significantly; however, the increases differed significantly among the SCIT groups (p<0.001). Specific IgG4 levels to D. farinae were highest in Hollister-Stier® (3.7±4.1 mg/L), followed by Novo-Helisen® (2.2±2.3 mg/L) and Tyrosine S® (0.7±0.5 mg/L). In addition, patients who were administered using Hollister-Stier® showed the most significant decrease in IgE/IgG4 ratio (p<0.001) and increase in blocking factor (p=0.009). Finally, according to IgE immunoblot results, the Hollister-Stier® group showed the most significant attenuation of IgE binding patterns among others. CONCLUSION: Currently available SCIT reagents induce different levels of specific IgG4, IgE/IgG4 ratio, and IgE-blocking factor.
Files in This Item:
T201603349.pdf Download
DOI
10.3349/ymj.2016.57.6.1427
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute of Allergy (알레르기연구소)
Yonsei Authors
박경희(Park, Kyung Hee) ORCID logo https://orcid.org/0000-0003-3605-5364
박중원(Park, Jung Won)
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
손영웅(Son, Young Woong)
신정우(Shin, Jung U) ORCID logo https://orcid.org/0000-0001-5259-6879
심다운(Sim, Da Woon)
이광훈(Lee, Kwang Hoon)
이상철(Lee, Sang Chul)
이재현(Lee, Jae Hyun) ORCID logo https://orcid.org/0000-0002-0760-0071
정경용(Jeong, Kyoung Yong) ORCID logo https://orcid.org/0000-0001-9887-1426
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151963
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse