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A Randomized Controlled Trial of Compression Rates during Cardiopulmonary Resuscitation

 Sung Oh Hwang  ;  Kyoung-Chul Cha  ;  Kyuseok Kim  ;  You Hwan Jo  ;  Sung Phil Chung  ;  Je Sung You  ;  Jonghwan Shin  ;  Hui Jai Lee  ;  Yoo Seok Park  ;  Seunghwan Kim  ;  Sang-cheon Choi  ;  Eun-Jung Park  ;  Won Young Kim  ;  Dong-Woo Seo  ;  Sungwoo Moon  ;  Gapsu Han  ;  Han Sung Choi  ;  Hyunggoo Kang  ;  Seung Min Park  ;  Woon Yong Kwon  ;  Eunhee Choi 
 Journal of Korean Medical Science, Vol.31(9) : 1491-1498, 2016 
Journal Title
 Journal of Korean Medical Science 
Issue Date
Age Factors ; Aged ; Aged, 80 and over ; Cardiopulmonary Resuscitation/methods* ; Emergency Medical Services ; Female ; Humans ; Male ; Middle Aged ; Out-of-Hospital Cardiac Arrest/mortality ; Out-of-Hospital Cardiac Arrest/therapy* ; Patient Discharge ; Sex Factors ; Survival Analysis ; Treatment Outcome
Basic Life Support ; Cardiac Arrest ; Cardiopulmonary Resuscitation
The objective of this study was to compare the efficacy of cardiopulmonary resuscitation (CPR) with 120 compressions per minute (CPM) to CPR with 100 CPM in patients with non-traumatic out-of-hospital cardiac arrest. We randomly assigned patients with non-traumatic out-of-hospital cardiac arrest into two groups upon arrival to the emergency department (ED). The patients received manual CPR either with 100 CPM (CPR-100 group) or 120 CPM (CPR-120 group). The primary outcome measure was sustained restoration of spontaneous circulation (ROSC). The secondary outcome measures were survival discharge from the hospital, one-month survival, and one-month survival with good functional status. Of 470 patients with cardiac arrest, 136 patients in the CPR-100 group and 156 patients in the CPR-120 group were included in the final analysis. A total of 69 patients (50.7%) in the CPR-100 group and 67 patients (42.9%) in the CPR-120 group had ROSC (absolute difference, 7.8% points; 95% confidence interval [CI], -3.7 to 19.2%; P = 0.183). The rates of survival discharge from the hospital, one-month survival, and one-month survival with good functional status were not different between the two groups (16.9% vs. 12.8%, P = 0.325; 12.5% vs. 6.4%, P = 0.073; 5.9% vs. 2.6%, P = 0.154, respectively). We did not find differences in the resuscitation outcomes between those who received CPR with 100 CPM and those with 120 CPM. However, a large trial is warranted, with adequate power to confirm a statistically non-significant trend toward superiority of CPR with 100 CPM. ( CLINICAL TRIAL REGISTRATION INFORMATION: www.cris.nih.go.kr, cris.nih.go.kr number, KCT0000231).
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1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
Yonsei Authors
박유석(Park, Yoo Seok) ORCID logo https://orcid.org/0000-0003-1543-4664
유제성(You, Je Sung) ORCID logo https://orcid.org/0000-0002-2074-6745
정성필(Chung, Sung Pil) ORCID logo https://orcid.org/0000-0002-3074-011X
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