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Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

DC FieldValueLanguage
dc.contributor.author김경민-
dc.contributor.author김세훈-
dc.contributor.author박성일-
dc.contributor.author신민우-
dc.contributor.author신원선-
dc.contributor.author원종윤-
dc.contributor.author이도연-
dc.contributor.author김도영-
dc.contributor.author김만득-
dc.date.accessioned2017-10-26T07:17:10Z-
dc.date.available2017-10-26T07:17:10Z-
dc.date.issued2016-
dc.identifier.issn1051-0443-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151837-
dc.description.abstractPURPOSE: To investigate feasibility, safety, and effect of transarterial chemoembolization using sorafenib on degree of tumor necrosis in a rabbit VX2 liver tumor model. MATERIALS AND METHODS: New Zealand White rabbits (n = 20) with a VX2 tumor were divided into two groups; one group was treated with hepatic arterial administration of 0.5 mL ethiodized oil alone (Lipiodol; Guerbet, Aulnay-sous-Bois, France) (transarterial embolization with Lipiodol [TAE-L] group), and one group was treated with 0.5 mL ethiodized oil plus 10 mg sorafenib (transarterial embolization with sorafenib [TAE-S] group). Liquid chromatography tandem mass spectrometry was used to measure sorafenib concentration in peripheral blood and tissue. Hepatic enzymes, vascular endothelial growth factor (VEGF), and hypoxia-inducible factor 1α (HIF-1α) were measured at 0, 24, and 72 hours after treatment. Histopathologic examination was performed to evaluate extent of tumor necrosis and normal parenchymal damage. RESULTS: Serum sorafenib concentration peaked at 2 hours after treatment. The mean tissue concentration was 406.8 times greater than the serum concentration. Aspartate aminotransferase and alanine aminotransferase levels were significantly elevated in the TAE-S group at 24 hours after treatment. Serum VEGF and HIF-1α concentrations were not significantly different between the TAE-L and TAE-S groups. Hepatic parenchymal damage was more severe in the TAE-S group. Mean fraction of tumor necrosis after treatment was significantly greater in the TAE-S group. CONCLUSIONS: Transarterial chemoembolization using sorafenib resulted in a high intrahepatic concentration of sorafenib. The degree of tumor necrosis was significantly greater in the TAE-S group compared with the TAE-L group, but more severe toxicity of normal liver tissue also occurred.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSociety of Cardiovascular and Interventional Radiology-
dc.relation.isPartOfJOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlanine Transaminase/blood-
dc.subject.MESHAnimals-
dc.subject.MESHAntineoplastic Agents/administration & dosage*-
dc.subject.MESHAntineoplastic Agents/blood-
dc.subject.MESHAntineoplastic Agents/pharmacokinetics*-
dc.subject.MESHAntineoplastic Agents/toxicity-
dc.subject.MESHAspartate Aminotransferases/blood-
dc.subject.MESHCarcinoma, Hepatocellular/blood-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCarcinoma, Hepatocellular/therapy*-
dc.subject.MESHChemoembolization, Therapeutic/adverse effects-
dc.subject.MESHChemoembolization, Therapeutic/methods*-
dc.subject.MESHEthiodized Oil/administration & dosage-
dc.subject.MESHFeasibility Studies-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/blood-
dc.subject.MESHLiver Neoplasms, Experimental/blood-
dc.subject.MESHLiver Neoplasms, Experimental/pathology-
dc.subject.MESHLiver Neoplasms, Experimental/therapy*-
dc.subject.MESHMale-
dc.subject.MESHNecrosis-
dc.subject.MESHNiacinamide/administration & dosage-
dc.subject.MESHNiacinamide/analogs & derivatives*-
dc.subject.MESHNiacinamide/pharmacokinetics-
dc.subject.MESHNiacinamide/toxicity-
dc.subject.MESHPhenylurea Compounds/administration & dosage*-
dc.subject.MESHPhenylurea Compounds/pharmacokinetics*-
dc.subject.MESHPhenylurea Compounds/toxicity-
dc.subject.MESHProtein Kinase Inhibitors/administration & dosage*-
dc.subject.MESHProtein Kinase Inhibitors/blood-
dc.subject.MESHProtein Kinase Inhibitors/pharmacokinetics*-
dc.subject.MESHProtein Kinase Inhibitors/toxicity-
dc.subject.MESHRabbits-
dc.subject.MESHTissue Distribution-
dc.subject.MESHVascular Endothelial Growth Factor A/blood-
dc.titleTransarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorGyoung Min Kim-
dc.contributor.googleauthorMan Deuk Kim-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJong Yun Won-
dc.contributor.googleauthorSung Il Park-
dc.contributor.googleauthorDo Yun Lee-
dc.contributor.googleauthorWonseon Shin-
dc.contributor.googleauthorMinwoo Shin-
dc.identifier.doi10.1016/j.jvir.2016.02.032-
dc.contributor.localIdA04899-
dc.contributor.localIdA01510-
dc.contributor.localIdA04594-
dc.contributor.localIdA04597-
dc.contributor.localIdA02443-
dc.contributor.localIdA02718-
dc.contributor.localIdA00385-
dc.contributor.localIdA00420-
dc.contributor.localIdA00296-
dc.relation.journalcodeJ01922-
dc.identifier.eissn1535-7732-
dc.identifier.pmid27179404-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S1051044316003833-
dc.contributor.alternativeNameKim, Gyoung Min-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNamePark, Sung Il-
dc.contributor.alternativeNameShin, Min Woo-
dc.contributor.alternativeNameShin, Won Seon-
dc.contributor.alternativeNameWon, Jong Yun-
dc.contributor.alternativeNameLee, Do Yun-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Man Deuk-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorPark, Sung Il-
dc.contributor.affiliatedAuthorShin, Min Woo-
dc.contributor.affiliatedAuthorShin, Won Seon-
dc.contributor.affiliatedAuthorWon, Jong Yun-
dc.contributor.affiliatedAuthorLee, Do Yun-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorKim, Man Deuk-
dc.contributor.affiliatedAuthorKim, Gyoung Min-
dc.citation.volume27-
dc.citation.number7-
dc.citation.startPage1086-
dc.citation.endPage1092-
dc.identifier.bibliographicCitationJOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.27(7) : 1086-1092, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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