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Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential

Authors
 Dae Hoon Kim  ;  Sooung Lee  ;  Youn Wook Chung  ;  Byeong Mo Kim  ;  Hanseul Kim  ;  Kunhong Kim  ;  Kyung Mi Yang 
Citation
 BioMed Research International, Vol.2016 : 8432759-8432759, 2016 
Journal Title
 BioMed Research International 
Issue Date
2016
MeSH
3T3-L1 Cells ; Animals ; Diabetes Mellitus/drug therapy* ; Diabetes Mellitus/genetics ; Diabetes Mellitus/pathology ; Humans ; Insulin/blood ; Insulin Resistance/genetics ; Liver/drug effects ; Liver/pathology ; Mice ; Mice, Obese ; Moraceae/chemistry ; Obesity/drug therapy* ; Obesity/genetics ; Obesity/pathology ; Plant Extracts/administration & dosage* ; Plant Extracts/chemistry ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/biosynthesis* ; Signal Transduction/drug effects
Abstract
Diabetes and obesity represent the major health problems and the most age-related metabolic diseases. Protein-tyrosine phosphatase 1B (PTP1B) has emerged as an important regulator of insulin signal transduction and is regarded as a pharmaceutical target for metabolic disorders. To find novel natural materials presenting therapeutic activities against diabetes and obesity, we screened various herb extracts using a chip screening allowing the determination of PTP1B inhibitory effects of the tested compounds using insulin receptor (IR) as the substrate. Cudrania tricuspidata leaves (CTe) had a strong inhibitory effect on PTP1B activity and substantially inhibited fat accumulation in 3T3-L1 cells. CTe was orally administrated to diet-induced obesity (DIO) mice once daily for 3 weeks after which changes in glucose, insulin metabolism, and fat accumulation were examined. Hepatic enzyme markers (aspartate aminotransferase, AST, and alanine aminotransferase, ALT) and total fat mass and triglyceride levels decreased in CTe-treated mice, whereas body weight and total cholesterol concentration slightly decreased. CTe increased the phosphorylation of IRS-1 and Akt in liver tissue. Furthermore, CTe treatment significantly lowered blood glucose levels and improved insulin secretion in DIO mice. Our results strongly suggest that CTe may represent a promising therapeutic substance against diabetes and obesity.
DOI
10.1155/2016/8432759
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소)
Yonsei Authors
김건홍(Kim, Kun Hong) ORCID logo https://orcid.org/0000-0001-5639-6372
김병모(Kim, Byeong Mo) ORCID logo https://orcid.org/0000-0002-0582-3132
양경미(Yang, Kyung Mi)
정연욱(Chung, Youn Wook) ORCID logo https://orcid.org/0000-0002-4382-1410
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151782
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