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Antiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential

DC FieldValueLanguage
dc.contributor.author김건홍-
dc.contributor.author양경미-
dc.contributor.author정연욱-
dc.contributor.author김병모-
dc.date.accessioned2017-10-26T07:14:19Z-
dc.date.available2017-10-26T07:14:19Z-
dc.date.issued2016-
dc.identifier.issn2314-6133-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/151782-
dc.description.abstractDiabetes and obesity represent the major health problems and the most age-related metabolic diseases. Protein-tyrosine phosphatase 1B (PTP1B) has emerged as an important regulator of insulin signal transduction and is regarded as a pharmaceutical target for metabolic disorders. To find novel natural materials presenting therapeutic activities against diabetes and obesity, we screened various herb extracts using a chip screening allowing the determination of PTP1B inhibitory effects of the tested compounds using insulin receptor (IR) as the substrate. Cudrania tricuspidata leaves (CTe) had a strong inhibitory effect on PTP1B activity and substantially inhibited fat accumulation in 3T3-L1 cells. CTe was orally administrated to diet-induced obesity (DIO) mice once daily for 3 weeks after which changes in glucose, insulin metabolism, and fat accumulation were examined. Hepatic enzyme markers (aspartate aminotransferase, AST, and alanine aminotransferase, ALT) and total fat mass and triglyceride levels decreased in CTe-treated mice, whereas body weight and total cholesterol concentration slightly decreased. CTe increased the phosphorylation of IRS-1 and Akt in liver tissue. Furthermore, CTe treatment significantly lowered blood glucose levels and improved insulin secretion in DIO mice. Our results strongly suggest that CTe may represent a promising therapeutic substance against diabetes and obesity.-
dc.description.statementOfResponsibilityopen-
dc.publisherHindawi Pub. Co.-
dc.relation.isPartOfBIOMED RESEARCH INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESH3T3-L1 Cells-
dc.subject.MESHAnimals-
dc.subject.MESHDiabetes Mellitus/drug therapy*-
dc.subject.MESHDiabetes Mellitus/genetics-
dc.subject.MESHDiabetes Mellitus/pathology-
dc.subject.MESHHumans-
dc.subject.MESHInsulin/blood-
dc.subject.MESHInsulin Resistance/genetics-
dc.subject.MESHLiver/drug effects-
dc.subject.MESHLiver/pathology-
dc.subject.MESHMice-
dc.subject.MESHMice, Obese-
dc.subject.MESHMoraceae/chemistry-
dc.subject.MESHObesity/drug therapy*-
dc.subject.MESHObesity/genetics-
dc.subject.MESHObesity/pathology-
dc.subject.MESHPlant Extracts/administration & dosage*-
dc.subject.MESHPlant Extracts/chemistry-
dc.subject.MESHProtein Tyrosine Phosphatase, Non-Receptor Type 1/biosynthesis*-
dc.subject.MESHSignal Transduction/drug effects-
dc.titleAntiobesity and Antidiabetes Effects of a Cudrania tricuspidata Hydrophilic Extract Presenting PTP1B Inhibitory Potential-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology-
dc.contributor.googleauthorDae Hoon Kim-
dc.contributor.googleauthorSooung Lee-
dc.contributor.googleauthorYoun Wook Chung-
dc.contributor.googleauthorByeong Mo Kim-
dc.contributor.googleauthorHanseul Kim-
dc.contributor.googleauthorKunhong Kim-
dc.contributor.googleauthorKyung Mi Yang-
dc.identifier.doi10.1155/2016/8432759-
dc.contributor.localIdA02279-
dc.contributor.localIdA03654-
dc.contributor.localIdA00289-
dc.relation.journalcodeJ00315-
dc.identifier.eissn2314-6141-
dc.relation.journalsince2012~-
dc.identifier.pmid26989693-
dc.relation.journalbefore~2012 Journal of Biomedicine & Biotechnology-
dc.contributor.alternativeNameKim, Kun Hong-
dc.contributor.alternativeNameYang, Kyung Mi-
dc.contributor.alternativeNameChung, Youn Wook-
dc.contributor.affiliatedAuthorYang, Kyung Mi-
dc.contributor.affiliatedAuthorChung, Youn Wook-
dc.contributor.affiliatedAuthorKim, Kun Hong-
dc.citation.volume2016-
dc.citation.startPage8432759-
dc.identifier.bibliographicCitationBIOMED RESEARCH INTERNATIONAL, Vol.2016 : 8432759, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Yonsei Cardiovascular Research Institute (심혈관연구소) > 1. Journal Papers

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