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Preclinical assessment of a modified Occlutech left atrial appendage closure device in a canine model

Authors
 Jung-Sun Kim  ;  Seul-Gee Lee  ;  Sung-Kyung Bong  ;  Se-Il Park  ;  Sung-Yu Hong  ;  Sanghoon Shin  ;  Chi Young Shim  ;  Geu-Ru Hong  ;  Donghoon Choi  ;  Yangsoo Jang  ;  Jai-Wun Park 
Citation
 INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.221 : 413-418, 2016 
Journal Title
 INTERNATIONAL JOURNAL OF CARDIOLOGY 
ISSN
 0167-5273 
Issue Date
2016
MeSH
Animals ; Atrial Appendage/surgery* ; Atrial Fibrillation/surgery* ; Disease Models, Animal ; Dogs ; Prosthesis Implantation*/instrumentation ; Prosthesis Implantation*/methods ; Septal Occluder Device* ; Stroke/prevention & control*
Keywords
Canine model ; Device study ; Left atrial appendage
Abstract
BACKGROUND: LAA occlusion has a similar stroke prevention efficacy compared to anticoagulation treatment for non-valvular atrial fibrillation. OBJECTIVE: The objective of this study was to assess the feasibility and safety of a modified Occlutech® left atrial appendage (LAA) closure device in a canine model. METHODS: The device was implanted in 10 dogs (33±1kg) using fluoroscopy and transesophageal echocardiography (TEE) guidance. The modified Occlutech® LAA occlusion device was compared with the current version, the Watchman device, and the Amplazter cardiac plug (ACP). LAA occlusion and anchoring to the LAA were evaluated. All dogs were assessed using angiography, TEE, and a gross anatomy examination. RESULTS: The 10 LAA occlusion devices were to be implanted into 10 dogs (5 modified Occlutech devices, 3 current version of Occlutech devices, 1 Watchman, and 1 ACP). LAA implantation was not performed in one dog due to transeptal puncture failure. The three current version of Occlutech devices were embolized immediately after implantation, so three modified devices of the same size were implanted securely without embolization. The mean implant size was 20.1±2.0mm. The devices chosen were a mean of 23.3±10.6% larger than the measured landing zone diameters. Post-implant angiography and TEE revealed well-positioned devices without pericardial effusion or impingement on surrounding structures. CONCLUSIONS: The results of this acute animal study suggested that a modified Occlutech® LAA occlusion device was feasible and had greater anchoring performance in canines. Additional large clinical studies are needed to evaluate safety and efficacy.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167527316314103
DOI
10.1016/j.ijcard.2016.07.048
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jung Sun(김중선) ORCID logo https://orcid.org/0000-0003-2263-3274
Shim, Chi Young(심지영) ORCID logo https://orcid.org/0000-0002-6136-0136
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Hong, Geu Ru(홍그루) ORCID logo https://orcid.org/0000-0003-4981-3304
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151770
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