Cited 14 times in
Comparative analysis of secretory factors from permanent- and deciduous-teeth periodontal ligament cells
DC Field | Value | Language |
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dc.contributor.author | 김기림 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 송제선 | - |
dc.contributor.author | 전미정 | - |
dc.contributor.author | 조성원 | - |
dc.contributor.author | 김성오 | - |
dc.date.accessioned | 2017-10-26T07:11:46Z | - |
dc.date.available | 2017-10-26T07:11:46Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/151726 | - |
dc.description.abstract | OBJECTIVE: Studies of regenerative therapies have focused on the paracrine effects of mesenchymal stem cells, but little has been revealed about the humoral factors of periodontal ligament (PDL) stem cells. The aim of this study was to identify and compare the secretory factors of human permanent- and deciduous-teeth PDL cells (P-PDL and D-PDL cells, respectively) in order to understand the characteristics of these cells and their potential applications in regenerative therapies. DESIGN: Conditioned media were collected from P-PDL and D-PDL cells (P-PDL-CM and D-PDL-CM, respectively). These media were analyzed with high-performance liquid-chromatography-coupled electrospray ionization tandem mass spectrometry and a cytokine membrane assay. In addition, Western blot analysis was performed to verify the differences between the two media. RESULTS: Cytokines related to neurogenesis (NT-3 and NT-4) and angiogenesis-related cytokines (EGF and IGF-1) were identified in P-PDL-CM. The expression levels of immune-response-related cytokines (interleukins I, II, and IV) and secreted proteins related to tissue degradation and catalytic activities (matrix metallopeptidase 1 (MMP1), Proteasome subunit, alpha type, 1 (PSMA1), and cullin 7 (CUL7)) were higher in D-PDL-CM. Vasorin (VASN) was expressed more strongly in P-PDL-CM, but tudor domain containing 7 (TDRD7) was expressed more strongly in D-PDL-CM in Western blot analysis. CONCLUSION: The cytokine expressions of the two cell types showed different patterns, especially in neurogenesis and immune responses. P-PDL cells are more suitable candidates for applications in regenerative therapies. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Pergamon Press | - |
dc.relation.isPartOf | ARCHIVES OF ORAL BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Chromatography, High Pressure Liquid | - |
dc.subject.MESH | Culture Media, Conditioned | - |
dc.subject.MESH | Cytokines/immunology* | - |
dc.subject.MESH | Cytokines/metabolism* | - |
dc.subject.MESH | Dentition, Permanent | - |
dc.subject.MESH | Electrophoresis, Polyacrylamide Gel | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Periodontal Ligament/cytology* | - |
dc.subject.MESH | Periodontal Ligament/metabolism* | - |
dc.subject.MESH | Spectrometry, Mass, Electrospray Ionization | - |
dc.subject.MESH | Tooth, Deciduous | - |
dc.title | Comparative analysis of secretory factors from permanent- and deciduous-teeth periodontal ligament cells | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Dentistry | - |
dc.contributor.department | Dept. of Oral Biology | - |
dc.contributor.googleauthor | Kirim Kim | - |
dc.contributor.googleauthor | Mijeong Jeon | - |
dc.contributor.googleauthor | Hyo-Seol Lee | - |
dc.contributor.googleauthor | Jung-Chul Park | - |
dc.contributor.googleauthor | Seok-Jun Moon | - |
dc.contributor.googleauthor | Seong-Oh Kim | - |
dc.contributor.googleauthor | Sung-Won Cho | - |
dc.contributor.googleauthor | Je Seon Song | - |
dc.identifier.doi | 10.1016/j.archoralbio.2016.07.003 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A01653 | - |
dc.contributor.localId | A02058 | - |
dc.contributor.localId | A03837 | - |
dc.contributor.localId | A00577 | - |
dc.contributor.localId | A03511 | - |
dc.contributor.localId | A00333 | - |
dc.relation.journalcode | J00225 | - |
dc.identifier.eissn | 1879-1506 | - |
dc.identifier.pmid | 27448989 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0003996916301716 | - |
dc.subject.keyword | Cytokine | - |
dc.subject.keyword | Deciduous teeth | - |
dc.subject.keyword | Periodontal ligament cells | - |
dc.subject.keyword | Permanent teeth | - |
dc.subject.keyword | Secretory factors | - |
dc.contributor.alternativeName | Kim, Ki Rim | - |
dc.contributor.alternativeName | Moon, Seok Jun | - |
dc.contributor.alternativeName | Park, Jung Chul | - |
dc.contributor.alternativeName | Song, Je Seon | - |
dc.contributor.alternativeName | Jeon, Mi Jeong | - |
dc.contributor.alternativeName | Cho, Sung Won | - |
dc.contributor.alternativeName | Kim, Seong Oh | - |
dc.contributor.affiliatedAuthor | Moon, Seok Jun | - |
dc.contributor.affiliatedAuthor | Song, Je Seon | - |
dc.contributor.affiliatedAuthor | Cho, Sung Won | - |
dc.contributor.affiliatedAuthor | Kim, Seong Oh | - |
dc.contributor.affiliatedAuthor | Jeon, Mi Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Ki Rim | - |
dc.citation.volume | 71 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 79 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF ORAL BIOLOGY, Vol.71 : 65-79, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 45739 | - |
dc.type.rims | ART | - |
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