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Mechanoresponsive Properties of the Periodontal Ligament

Authors
 L. Huang  ;  B. Liu  ;  J.Y. Cha  ;  G. Yuan  ;  M. Kelly  ;  G. Singh  ;  S. Hyman  ;  J.B. Brunski  ;  J. Li  ;  J.A. Helms 
Citation
 Journal of Dental Research, Vol.95(4) : 467-475, 2016 
Journal Title
 Journal of Dental Research 
ISSN
 0022-0345 
Issue Date
2016
MeSH
Animals ; Cell Proliferation ; Collagen/metabolism ; Finite Element Analysis ; Immunohistochemistry ; Mastication/physiology ; Mice ; Microscopy, Electron, Scanning ; Mitosis/physiology ; Periodontal Ligament/physiology* ; Stress, Mechanical ; Tooth Eruption/physiology ; Tooth Movement Techniques
Keywords
collagen ; enthesis ; mechanical ; orthodontic ; proliferation ; tooth movement
Abstract
The periodontal ligament (PDL) functions as an enthesis, a connective tissue attachment that dissipates strains created by mechanical loading. Entheses are mechanoresponsive structures that rapidly adapt to changes in their mechanical loading; here we asked which features of the PDL are sensitive to such in vivo loading. We evaluated the PDL in 4 physiologically relevant mechanical environments, focusing on mitotic activity, cell density, collagen content, osteogenic protein expression, and organization of the tissue. In addition to examining PDLs that supported teeth under masticatory loading and eruptive forces, 2 additional mechanical conditions were created and analyzed: hypoloading and experimental tooth movement. Collectively, these data revealed that the adult PDL is a remarkably quiescent tissue and that only when it is subjected to increased loads--such as those associated with mastication, eruption, and orthodontic tooth movement-does the tissue increase its rate of cell proliferation and collagen production. These data have relevance in clinical scenarios where PDL acclimatization can be exploited to optimize tooth movement
Full Text
http://journals.sagepub.com/doi/abs/10.1177/0022034515626102
DOI
10.1177/0022034515626102
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
차정열(Cha, Jung Yul)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/151699
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